Heart & Health Study

Summary

We hope to learn more about why certain people have higher levels of the 5-LO protein and whether taking fish oil supplements gives such individuals greater protection than others against cardiovascular disease. The 5-LO protein is important in the development of heart disease because it converts a type of oil from meat into a compound that can cause inflammation in blood vessels. This inflammation is a major cause of heart disease.

Researchers think that people with higher levels of a protein called 5-LO in their white blood cells may have a healthier response to using fish oil supplements than do people with lower levels of this protein.

Conditions

• Heart Disease

Interventions

DIETARY_SUPPLEMENT

Fish Oil

capsules, 5.0 g/d fish oil concentrate (3.0 g/d EPA + DHA), 6 weeks

DIETARY_SUPPLEMENT

Placebo

capsule, 5.0 g/d corn/soybean oil (50/50 mixture), 6 weeks

Sponsors & Collaborators

• National Center for Complementary and Integrative Health (NCCIH)

  collaborator NIH

• Office of Dietary Supplements (ODS)

  collaborator NIH

• University of California, Davis

  collaborator OTHER

• USDA Beltsville Human Nutrition Research Center

  collaborator FED

• Alta Bates Summit Medical Center

  collaborator OTHER

• University of Southern California

  collaborator OTHER

• USDA, Western Human Nutrition Research Center

  lead FED

Principal Investigators

• Charles B Stephensen, PhD · UC Davis & U.S. Department of Agriculture

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Model

PARALLEL

Eligibility

Min Age

20 Years

Max Age

59 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2006-12-31

Primary Completion

2008-07-31

Completion

2008-07-31

Countries

• United States

Study Locations