Omega-3 Fatty Acids in Elderly Patients With Acute Myocardial Infarction

Summary

The aim of the present study is to investigate the possible effects of supplementation with 1.8 g/day of n-3 polyunsaturated fatty acids on cardiovascular morbidity and mortality during a follow-up period of 2 years in an elderly population after having experienced an acute myocardial infarction.

The hypothesis is that this supplementation on top of modern therapy will reduce the combined cardiovascular end-point of death, non-fatal myocardial infarction, stroke, revascularizations or hospitalization for new or worsened heart failure with at least 30%.

Conditions

• Myocardial Infarction
• Heart Failure
• Myocardial Revascularization
• Atrial Fibrillation

Interventions

DRUG

Pikasol

Pikasol®, 3 capsules (1.8 g EPA+DHA)/day

OTHER

Corn oil

Corn oil (56% linoleic acid, 32% oleic acid, 10% palmitic acid), unchanged and according to the manufacturer

Sponsors & Collaborators

• University Hospital, Akershus

  collaborator OTHER

• Asker & Baerum Hospital

  collaborator OTHER

• Helse Stavanger HF

  collaborator OTHER_GOV

• Oslo University Hospital

  lead OTHER

Principal Investigators

• Harald Arnesen, MD Phd · Center for Clinical Heart Research

• Svein Solheim, MD phd · Center for Clinical Heart Research

• Ingebjørg Seljeflot, Phd · Center for Clinical Heart Research

• Kristian Laake, MD · Center for Clinical Heart Research

• Peder Myhre, MD · Center for Clinical Heart Research

• Are A Kalstad, MD · Center for Clinical Heart Research

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Model

PARALLEL

Eligibility

Min Age

70 Years

Max Age

82 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2012-11-30

Primary Completion

2020-06-26

Completion

2020-06-26

Countries

• Norway

Study Locations