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Changes in the Immunomodulatory Properties of Adipose Stromal Cells Due to Hemarthrosis After Knee Injury

NCT05687331 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 20

Last updated 2023-01-18

No results posted yet for this study

Summary

The goal of this observational study is to gain insight in the natural course of pro-inflammatory factors and hemarthrosis in patients older than 18 with a recent knee trauma. The main question\[s\] it aims to answer are:

* What is the natural course of pro-inflammatory factors and hemarthrosis in knee trauma?
* What are the effects of inflammation and hemarthrosis on the anti-inflammatory potential of ASC's in order to better determine eligible patients and circumstances for ASC's therapy?

Participants will:

* undergo blood withdrawal
* undergo knee arthrocentesis for synovial fluid sample collection
* physical examination
* fill out a questionnaire on knee complaints

Conditions

  • Post-Traumatic Osteoarthritis of Knee
  • Knee Injuries
  • Hemarthrosis

Interventions

PROCEDURE

knee arthrocentesis

arthrocentesis of the knee joint to gather a synovial fluid sample

PROCEDURE

venipuncture

Peripheral venipuncture to gather a blood sample

DIAGNOSTIC_TEST

MRI-scan

MRI-scan of the knee

DIAGNOSTIC_TEST

Physical examination

Physical examination of the injured knee

OTHER

KOOS questionnaire

KOOS questionnaire of the injured knee

Sponsors & Collaborators

  • Radboud University Medical Center

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-04-05
Primary Completion
2023-04-01
Completion
2024-04-01

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05687331 on ClinicalTrials.gov