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Evaluation of Patients With Knee Osteoarthritis Receiving a Prosthesis

NCT03644420 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 22

Last updated 2018-08-23

No results posted yet for this study

Summary

Patients with osteoarthritis of the knee undergo visible joint changes in radiology and Magnetic resonance imaging (MRI) tests, but also clinically and histologically. The area of greatest change is at the subchondral/cartilage bone junction.

Investigators will determine the association between preoperative clinical evaluation (IKDC and Womac scores), radiological classifications and histopathology.

In addition, the role of inflammation in the pathogenesis of osteoarthritis is being given major interest, and inflammation is closely linked with vascularization. It was recently demonstrated that dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) could identify the subchondral bone marrow vascularization changes occurring in osteoarthritis in animals.

These changes appeared before cartilage lesions were visible and were correlated with osteoarthritis severity. Thus the opportunity to obtain an objective assessment of bone vascularization in non-invasive conditions in humans might help better understanding osteoarthritis pathophysiology and finding new biomarkers. Investigators hypothesized that, as in animals, DCE-MRI has the ability to identify subchondral bone marrow vascularization changes in human osteoarthritis.

Conditions

  • Osteoarthritis, Knee
  • Perfusion
  • Bone Marrow
  • Magnetic Resonance Imaging

Interventions

DIAGNOSTIC_TEST

Clinical evaluation

Functional scores for the pathological joint will be determined

DIAGNOSTIC_TEST

Radiology

DIAGNOSTIC_TEST

Dynamic contrast-enhanced magnetic resonance imaging

Patients will be examined using a 3T MR scanner (MR 750W, General Electrics, Milwaukee, WI) with a dedicated knee coil. Subchondral bone marrow vascularization in medial and lateral femorotibial compartments will be assessed with DCE-MRI and lesions will be graded on MR images.

DIAGNOSTIC_TEST

Evaluation of histological status

Upper tibial resection pieces will be collected and the vascularization will be determined according to the OARSI score

Sponsors & Collaborators

  • Institut de Prévention et de Recherche sur l'Ostéoporose

    collaborator UNKNOWN

  • Lille Catholic University

    lead OTHER

Principal Investigators

  • Raphael Coursier, MD · Groupement des Hôpitaux de l'Institut Catholique de Lille

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-05-31
Primary Completion
2016-04-30
Completion
2016-12-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03644420 on ClinicalTrials.gov