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Substrate Utilization, Exercise Performance, and Skeletal Muscle Response to Energy Deficit and Altitude Acclimatization

NCT02731066 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 21

Last updated 2017-11-06

No results posted yet for this study

Summary

This research will evaluate nutrition requirements for missions at high altitude (i.e. \>7800 feet above sea level) and the information obtained can be used to optimize nutrient content specifications for combat rations.

The objectives are:

1. Determine whether loss of lean body mass resulting from negative calorie balance over a 22-d period at high altitude can be prevented by increasing dietary protein intake.
2. Determine the efficacy of carbohydrate (glucose and fructose) supplementation on aerobic exercise performance at sea level, acute exposure to high altitude, and in response to 22-d period of negative calorie balance at high altitude.
3. Determine cognitive function, sleep patterns, and behavioral responses to high altitude and underfeeding.
4. Determine appetite and eating behavior in response to high altitude and sustained underfeeding.
5. Examine the effects of high altitude, negative calorie balance, dietary intake manipulations on gut health.

Conditions

Interventions

OTHER

Standard pro

Volunteers will receive dietary protein at 1.0 ± 0.2 g/kg/d.

OTHER

High pro

Volunteers will receive dietary protein at 2.0 ± 0.2 g/kg/d.

OTHER

carbo bev

During aerobic performance testing, volunteers will receive a beverage containing 80 g glucose + 65 g fructose consumed at a rate providing \~1.8 g carbohydrate/min.

OTHER

placebo bev

During aerobic performance testing, volunteers will receive a volume and flavor-matched, non-nutritive placebo beverage.

Sponsors & Collaborators

  • Eastern Michigan University

    collaborator OTHER

  • United States Army Research Institute of Environmental Medicine

    lead FED

Principal Investigators

  • Stefan M Pasiakos, PhD · US Army Research Institute of Environmental Medicine

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
42 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-03-31
Primary Completion
2016-09-30
Completion
2016-09-30

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02731066 on ClinicalTrials.gov