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The Phthalate-Allergen Immune Response Study

NCT02688478 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2019-08-02

No results posted yet for this study

Summary

Phthalates are commonly used plasticizers that have been linked to asthma in epidemiological studies. The investigators are researching effects of phthalates on airway immunology and lung function, and on allergic responses by doing an inhaled allergen challenge. After exposing participants to either filtered air or carefully controlled levels of phthalate in our exposure chamber we will collect samples from the nose and the upper airways, by rinsing the nose with saltwater or performing small brushings. The investigators will also collect a bronchial samples by bronchoscopy after each exposure. After 2 weeks, the entire procedure will be repeated with the alternate exposure.

Conditions

Interventions

OTHER

Phthalate

Delivered by inhalation on day 1 of the triad

OTHER

Filtered Air

Delivered by inhalation on day 1 of the triad

OTHER

Allergen

Subject specific allergen is delivered by inhalation on day 1 of the triad

Sponsors & Collaborators

  • University of British Columbia

    lead OTHER

Principal Investigators

  • Christopher Carlsten, MD, MPH · University of British Columbia

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
19 Years
Max Age
49 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-02-02
Primary Completion
2020-05-07
Completion
2021-05-07

Countries

  • Canada

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02688478 on ClinicalTrials.gov