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The GlasVEGAS Study (Glasgow Visceral & Ectopic Fat With Weight Gain in South AsianS)

NCT02399423 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 35

Last updated 2023-09-18

No results posted yet for this study

Summary

South Asians have a much higher risk of diabetes compared to Europeans and investigators don't know why this is. Investigators think that South Asians' capacity to store fat safely under the skin is lower than Europeans, so they start to store fat around internal organs and in liver and muscle, and at lower body weights than Europeans. These increased levels of internal fat storage are thought to increase risk of diabetes.

The purpose of the study therefore is to investigate whether there are differences with weight gain and weight loss in fat storage, fat cell function and metabolic risk factors, in South Asians compared with Europeans. Investigators will compare South Asian and European men at the start of the study, after they have gained about 7% body weight, and again after they have lost 7-15% body weight (from peak weight) to see how gaining and losing weight affects fat storage within the body and the function of fat cells. Investigators will also assess the effect of weight gain and weight loss on metabolism, fitness and risk factors for diabetes and heart disease.

Conditions

Interventions

BEHAVIORAL

Weight gain

Weight gain of 7% body weight over 4-6 weeks by ingesting an extra 1500-2000 kcal/day

BEHAVIORAL

Weight loss

Weight loss of 7-15% body weight over 12 weeks by increased exercise and either an alternate day fasting dietary regime or a weight watchers dietary regime

Sponsors & Collaborators

  • Göteborg University

    collaborator OTHER

  • University of Pisa

    collaborator OTHER

  • University of Glasgow

    lead OTHER

Principal Investigators

  • Naveed Sattar, MD PhD · Univesity of Glasgow

  • Jason MR Gill, PhD · Univesity of Glasgow

Study Design

Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-03-11
Primary Completion
2018-03-08
Completion
2018-07-04

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02399423 on ClinicalTrials.gov