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Role of Immune System in Obesity-related Inflammation and Cardiometabolic Risk

NCT01104220 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 144

Last updated 2025-10-23

No results posted yet for this study

Summary

The purpose of this study is to learn more about how the body stores fat in and around organs (for example in the liver) and why this affects some people's health more than others. Understanding this may lead to better treatments for diseases such as diabetes and cardiovascular disease.

Conditions

  • Non-alcoholic Fatty Liver Disease
  • Metabolic Syndrome
  • Metabolically Abnormal Obesity
  • Metabolically Normal Obesity
  • Obesity

Interventions

OTHER

Weight loss

Bariatric surgery-induced weight loss to achieve \~20%-30% reduction in initial body weight

Sponsors & Collaborators

  • Pfizer

    collaborator INDUSTRY

  • Washington University School of Medicine

    lead OTHER

Principal Investigators

  • Samuel Klein, M.D. · Washington University School of Medicine

Study Design

Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-04-30
Primary Completion
2026-09-30
Completion
2026-12-31

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01104220 on ClinicalTrials.gov