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Fatty Acid Regulation of Platelet Function in Diabetes

NCT02373332 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 90

Last updated 2021-06-03

No results posted yet for this study

Summary

This study investigates the potential protective effects of altering fatty acid in the platelet as a method for prevention of platelet activation and thrombosis in type 2 diabetes mellitus. Fatty acids (omega-3 and omega-6) and their oxidized lipids will be evaluated for protection from agonist-mediated platelet activation in platelets from type 2 diabetics and healthy controls.

Conditions

Interventions

OTHER

omega-3 and -6 fatty acids and their 12-LOX oxylipins

platelets from healthy subjects and T2DM patients will be isolated from their blood and treated with omega-3 and -6 fatty acids and their 12-LOX oxylipins of those fatty acids followed by assessment of protection from agonist-induced platelet activation and thrombosis

Sponsors & Collaborators

Principal Investigators

  • Michael Holinstat, PhD · University of Michigan

Eligibility

Min Age
21 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-08-31
Primary Completion
2019-05-21
Completion
2019-05-21

Countries

  • United States

Study Locations

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Diseases
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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02373332 on ClinicalTrials.gov