Thrombosis refers to formation of blood clots within blood vessels, which can obstruct blood flow and cause major complications such as pulmonary embolism, stroke, or organ ischemia. Venous thromboembolism is a major preventable cause of morbidity and mortality.
The European Commission expanded Hympavzi approval to patients 12 and older with hemophilia A or B with inhibitors. Phase 3 data showed a 93% reduction in mean treated annualized bleeding rate versus on-demand therapy.
The FDA has issued draft guidance that may speed approval pathways for rare disease therapies using genome editing technologies, potentially benefiting CRISPR Therapeutics' pipeline of six clinical-stage candidates.
Switzerland-based CRISPR Therapeutics stands to benefit from increased Casgevy sales following partner Vertex Pharmaceuticals' fourth-quarter results, with five additional gene-editing therapies in clinical trials targeting larger patient populations.
International researchers have identified a specific antibody mutation that causes rare but serious blood clots after adenovirus-based COVID-19 vaccines or natural adenovirus infection, providing a roadmap for safer vaccine design.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07597239 |
Thromboelastography With Platelet Mapping to Guide Antiplatelet Therapy After Lower Extremity Revascularization |
ACTIVE_NOT_RECRUITING | NA |
| NCT07580469 |
Platelets and Extracorporeal Membrane Oxygenation Veno-venous |
NOT_YET_RECRUITING | |
| NCT07523880 |
Multi-Omics-Based Novel Thrombosis and Bleeding Markers and Risk Model for CHD |
RECRUITING | |
| NCT07519304 |
Effectiveness of a Needle-free Connector With Anti-reflux Technology in Reducing Complications From Long Peripheral Venous Catheters in Hospitalised Adult Patients: Randomised Clinical Trial |
NOT_YET_RECRUITING | NA |
| NCT07498517 |
Safety and Efficacy of a Single Dose of Gruticibart to Prevent CRT |
NOT_YET_RECRUITING | PHASE2 |
| NCT07377097 |
Effects of Sweetener Consumption on Risk Factors for Heart Disease in Prediabetic Subjects |
NOT_YET_RECRUITING | NA |
| NCT07372716 |
Safety of Perioperative Anticoagulation Management in People With Active Cancer Undergoing Cancer-Related Surgery or Procedures (ACE-HIGH Study) |
NOT_YET_RECRUITING | NA |
| NCT07358416 |
Complications and Antiplatelet and Anticoagulant Therapy in Vascular Surgery. |
ACTIVE_NOT_RECRUITING | |
| NCT07352072 |
Incidence of Bleeding, Thrombosis and Transfusion Requirements in ICU Patients With COVID-19 Supported With Veno-venous Extracorporeal Membrane Oxygenation |
NOT_YET_RECRUITING | |
| NCT07301892 |
Generative AI Impact on Rheumatoid Arthritis Complications Diagnosis |
RECRUITING |
