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Taste Physiology in Healthy, Normal-weight Volunteers

NCT02255812 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2014-10-03

No results posted yet for this study

Summary

Taste physiology describes five main taste qualities in humans: sweet, sour, salty, umami and bitter. The receptors found on the tongue are also found in the entire gut. The correlation of stimulation of these gut receptors and brain activity has not yet been examined. The objectives are to investigate the effect of different taste substances on i) regional brain activity and ii) satiation peptide release.

Conditions

  • Exploratory Behavior

Interventions

DIETARY_SUPPLEMENT

Single intragastric instillation of 200 mL tap water via nasogastric tube

DIETARY_SUPPLEMENT

Single intragastric instillation of 2 g citric acid in 200 mL tap water via nasogastric tube

DIETARY_SUPPLEMENT

Single intragastric instillation of 2 g salt in 200 mL tap water via nasogastric tube

DIETARY_SUPPLEMENT

Single intragastric instillation of 0.017 g quinine in 200 mL tap water via nasogastric tube

DIETARY_SUPPLEMENT

Single intragastric instillation of 1 g monosodium glutamate in 200 mL tap water via nasogastric tube

DIETARY_SUPPLEMENT

Single intragastric instillation of 25 g glucose in 200 mL tap water via nasogastric tube

Sponsors & Collaborators

  • University Hospital, Basel, Switzerland

    lead OTHER

Principal Investigators

  • Christoph Beglinger, MD · University Hospital, Basel, Switzerland

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-03-31
Primary Completion
2013-10-31
Completion
2013-10-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02255812 on ClinicalTrials.gov