Exercise in Air Pollution and Lung Health in Asthmatics

Summary

When exposed to air pollution, the asthma symptoms are aggravated and lung function is impaired. Due to high breathing rates and volumes, physically active individuals are at particular risk of lung health impairment due to the high breathing rates and volumes. Greater doses of air pollutants reach deeper areas in the lungs where they can trigger asthma-symptoms. When treating these symptoms with inhaled beta-2-agonists the airways widen even more, allowing the air pollutants to reach even deeper areas of the lung. With this study the investigators investigate how inhaled beta-2-agonists affect athletic capacity and lung health in physically active asthmatics.

Conditions

• Exercise-induced Bronchoconstriction
• Air Pollution

Interventions

OTHER

Rest (Sitting on chair)

Study participants will sit on a chair for 60min. This is to simulate physical resting condition.

OTHER

Cycling exercise

Study participants will exercise on a cycle ergometer for 45min. Participants will start their 30-min long constant workload exercise test test 60-min after the drug intervention. The exercise test will be set to a resistance of 50% of the maximal wattage that was reached on the graded exercise test on the screening day. The cycling exercise intervention will follow the rest-intervention.

DRUG

Salbutamol inhalation

Study participants will be exposed to 400ug of salbutamol prior to entering the air pollution chamber.

DRUG

Placebo inhalation

Study participants will inhale a placebo (placebo for salbutamol) prior to entering the air pollution chamber

OTHER

Diesel Exhaust Exposure

Participants will be exposed to PM2.5 of 300 μg/m3

OTHER

Filtered air

Participants will be breathing filtered air

Sponsors & Collaborators

• Canadian Academy of Sport and Exercise Medicine (CASEM)

  collaborator UNKNOWN

• Natural Sciences and Engineering Research Council, Canada

  collaborator OTHER

• Fraser Basin Council

  collaborator UNKNOWN

• University of British Columbia

  lead OTHER

Principal Investigators

• Michael S Koehle, MD, PhD · University of British Columbia

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Model

CROSSOVER

Eligibility

Min Age

19 Years

Max Age

40 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2015-05-31

Primary Completion

2016-08-31

Completion

2021-05-31

Countries

• Canada

Study Locations