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Adaptation to Ozone in Individuals With Asthma/Exercise-induced Bronchoconstriction

NCT05105529 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2022-06-02

No results posted yet for this study

Summary

Researchers found that impairments in the cardiopulmonary system caused by acute exposure to ozone were outweighed by repeated exposures to ozone. The goal of this study is to confirm there will be an adaptation similar to what was previously proved but in individuals with asthma and exercise-induced bronchoconstriction (EIB). The purpose is to examine adaptive responses in a randomized cross-over trial in which physically active individuals will perform submaximal exercise on five days in ozone and filtered air exposures separated by a washout period.

Conditions

  • Asthma
  • Asthma, Exercise-Induced
  • Exercise Induced Asthma
  • Exercise Induced Bronchospasm

Interventions

BEHAVIORAL

Exercise

Cycling at 60% of VO2max on a cycle ergometer for 30 minutes

OTHER

Ozone

Breathing 170ppb ozone

OTHER

Filtere Air

Breathing filtered air

Sponsors & Collaborators

  • University of British Columbia

    lead OTHER

Principal Investigators

  • Michael Koehle, MD PhD · Professor

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-01-01
Primary Completion
2023-01-31
Completion
2023-02-28

Countries

  • Canada

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05105529 on ClinicalTrials.gov