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The Role of the FTO Gene in Reward System Activation in Obese and Healthy Subjects

NCT01863212 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 500

Last updated 2013-05-27

No results posted yet for this study

Summary

In order to investigate if individuals, carrying genetic variants predisposing to obesity, respond differently to visual presented food images than non-carriers the investigators aim to screen 500 people for a common risk variant in the FTO gene. From those 500 screened 40 subjects, 20 homozygous for the risk allele and 20 homozygous for a non risk allele will be selected for the second step in the study. This part involves the fMRI technique to visualize the brain response, focus on reward system activation, when food images are visually presented in the scanner. Factors regarding eating behavior, sleep, physical exercise and relation to food are investigated in the first part of the study as well as clinical parameters such as BMI.

Conditions

Interventions

PROCEDURE

Blood sampling for genetic analyse

Blood sampling are performed at the initiation visit in order to screen for allele variants

BEHAVIORAL

Stroop test

Selective attention test where subjects, in one minute, names the ink color of several words without naming the word itself.

OTHER

fMRI

Functional Magnetic Resonance Imaging, performed to view brain activity

Sponsors & Collaborators

  • Uppsala University

    lead OTHER

Principal Investigators

  • Christian Benedict, PhD · dep. Neuroscience, Uppsala University

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
37 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-09-30
Primary Completion
2014-09-30
Completion
2014-09-30

Countries

  • Sweden

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01863212 on ClinicalTrials.gov