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Neural Mechanisms for Reducing Interference During Episodic Memory Formation

NCT05092100 · Status: ENROLLING_BY_INVITATION · Phase: NA · Type: INTERVENTIONAL · Enrollment: 737

Last updated 2024-09-19

No results posted yet for this study

Summary

Healthy individuals from the University of Oregon and surrounding community will be recruited for participation in behavioral, fMRI and eye tracking experiments that investigate human memory. Recruitment will involve emails, flyers, and local advertisements. Individuals between the ages of 18-80 (or 18-35 for some studies) will be eligible.

The broad objective of the research is to understand how humans form distinct memories for similar experiences. Experimental sessions will involve studying and trying to remember various images (e.g., images of natural scenes). The intervention will involve manipulating the similarity and/or learning protocol for the studied images. Outcome measures will include (a) behavioral measures of memory, and/or (b) fMRI measures of hemodynamic activity, and/or (c) eye tracking measures of gaze direction. Experimental sessions will last approximately 1-3 hours.

Conditions

  • Behavior

Interventions

BEHAVIORAL

Visual stimulus similarity

Visual stimulus similarity will be varied in order to test for effects on memory. Learning protocol (the order and frequency with which stimuli are learned) will also be varied.

OTHER

fMRI

fMRI will be used to measure patterns of BOLD activity during learning.

BEHAVIORAL

Eye tracking

Eye tracking will be used to measure patterns of eye movements when viewing images.

Sponsors & Collaborators

  • University of Oregon

    lead OTHER

Principal Investigators

  • Brice A Kuhl, Ph.D. · University of Oregon

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-09-29
Primary Completion
2025-12-31
Completion
2026-01-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05092100 on ClinicalTrials.gov