Once-Daily Oral Dose of BeneFlax to Healthy Older Adults

Summary

The investigators are investigating whether the flax lignan, secoisolariciresinol diglucoside, decreases oxidative stress and inflammation. The flax seed lignan is believed to be broken down in the body to produce the health benefits of flax. Flax lignan is separated from the whole flax seed as this compound is believed to have health effects. Decreasing oxidative stress and inflammation should improve a number of the problems associated with aging. This intervention consists of 600 milligrams of the flax lignan SDG daily or an equivalent amount of whey protein.

The investigators are comparing lignan to a placebo (whey powder) to examine whether a dietary intervention (i.e. flax seed containing lignan) might decrease oxidative stress and inflammation.

Conditions

• Oxidative Stress
• Inflammation
• Aging
• Pain

Interventions

DIETARY_SUPPLEMENT

secoisolariciresinol diglucoside, vitamin D

SDG supplementation as a packet of 1.6g/day of BeneFlax containing 600 mg SDG for 24 weeks Vitamin D Natural Product Number (NPN) 80003663 WN Pharmaceuticals Natural Factors Whey Factors

Sponsors & Collaborators

• Saskatchewan Health Research Foundation

  collaborator OTHER

• University of Saskatchewan

  lead OTHER

Principal Investigators

• Jennifer Jones, MD, FRCPC · University of Saskatchewan

• Jane Alcorn, DVD, PhD · University of Saskatchewan

• Susan Whiting, PhD · University of Saskatchewan

• Kerry Mansell, BSP, PharmD · University of Saskatchewan

• Sharyle Fowler, MD · University of Saskatchewan

• Lilian Thorpe, MD, PhD · University of Saskatchewan

• Thomas Hadjistavropoulos, PhD, RD · University of Regina

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

60 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2013-04-30

Primary Completion

2014-11-30

Completion

2014-11-30

Countries

• Canada

Study Locations