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Clinical Value of Remote Ischemic Preconditioning

NCT01740102 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 92

Last updated 2016-08-04

No results posted yet for this study

Summary

Objectives: Despite utilization of available means for cardioprotection during cardiac surgery, myocardial injury still occurs. Further improvement of cardioprotection is therefore necessary. Remote ischemic preconditioning (RIPC) is an easy and non-invasive method. Laboratory research has shown promising results regarding myocardial survival during open heart surgery, but the clinical value of RIPC is still largely unknown. The investigators hypothesize that RIPC before coronary artery bypass grafting (CABG) reduces the incidence of postoperative atrial fibrillation (POAF).

Conditions

Interventions

PROCEDURE

RIPC

The remote ischemic preconditioning will consist of three sequential sphygmomanometer cuff inflations. The cuff will be inflated up to 200 mmHg for 5 minutes and then deflated for 5 minutes. This cycle will be performed three times in total. The entire preconditioning will therefore last for 25 minutes.

Sponsors & Collaborators

  • Helse Nord-Trøndelag HF

    collaborator OTHER

  • Namsos Hospital

    collaborator OTHER

  • Sykehuset Innlandet HF

    collaborator OTHER

  • Helse Møre og Romsdal HF

    collaborator OTHER_GOV

  • Norwegian University of Science and Technology

    lead OTHER

Principal Investigators

  • Alexander Wahba, MD prof · Faculty of Medicine Norwegian University of Science and Technology Trondheim, Norway, and Department of Cardiothoracic Surgery, St. Olavs Hospital, Trondheim, Norway.

  • Lars Erik B Krogstad · Faculty of Medicine Norwegian University of Science and Technology Trondheim, Norway.

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-08-31
Primary Completion
2013-01-31
Completion
2013-09-30

Countries

  • Norway

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01740102 on ClinicalTrials.gov