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Effect of Remote Ischemic Preconditioning in Patient Undergoing Cardiac Bypass Surgery

NCT00397163 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 200

Last updated 2023-11-29

No results posted yet for this study

Summary

During coronary artery bypass graft surgery, injury occurs to the heart muscle. Some of this injury is due to the deprivation of oxygen and nutrients to the heart (a process called ischemia) during the surgery itself. The objective of this study is to examine whether remote ischaemic preconditioning (RIPC), in which the application of transient ischemia to the forearm and thigh (through the inflation of blood pressure cuffs placed on the right upper arm and upper thigh) may reduce the injury to the heart muscle sustained during cardiac surgery.

The study hypothesis is: remote ischemic preconditioning will protect the heart and improve short-term clinical outcomes during coronary artery bypass graft surgery.

Conditions

Interventions

PROCEDURE

Remote ischemic preconditioning

Blood pressure cuff inflation

PROCEDURE

Placebo

Deflated cuff on upper arm and thigh for 20 min

Sponsors & Collaborators

  • University College London Hospitals

    lead OTHER

Principal Investigators

  • Derek M Yellon, PhD DSc · The Hatter Cardiovascular Institute, UCL.

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-12-31
Primary Completion
2017-01-13
Completion
2017-01-13

Countries

  • United Kingdom

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00397163 on ClinicalTrials.gov