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A Study of Remote Ischaemic Preconditioning in Patients With Atherosclerosis Undergoing Vascular Surgery

NCT02689414 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 98

Last updated 2018-02-28

No results posted yet for this study

Summary

The purpose of this study is to evaluate the effect of preoperative remote ischaemic preconditioning (RIPC) on organ damage and the functional characteristics of arteries in patients undergoing vascular surgery. In addition, we investigate the connection between RIPC and changes in the functional characteristics of arteries and low molecular weight metabolites.

Conditions

Interventions

PROCEDURE

Remote ischaemic preconditioning

Ischaemia is achieved by using a blood pressure cuff on an arm by raising the cuff pressure to 200 mm Hg or to a value that is 20 mm Hg greater than the patient's systolic blood pressure - if the patient's systolic blood pressure is more than 180 mm Hg. The intervention starts simultaneously with the induction of anaesthesia or a few minutes earlier.

PROCEDURE

Control to RIPC

Venous pressure is achieved by using a blood pressure cuff on an arm by raising the cuff pressure to 10-20 mm Hg. The intervention starts simultaneously with the induction of anaesthesia or a few minutes earlier.

Sponsors & Collaborators

  • Tartu University Hospital

    lead OTHER

Principal Investigators

  • Urmas Lepner, MD-PhD · Tartu University Hospital

  • Joel Starkopf, MD-PhD · Tartu University Hospital

  • Mihkel Zilmer, MD-PhD · University of Tartu

  • Jaak Kals, MD-PhD · Tartu University Hospital

  • Karl Kuusik, MD · University of Tartu

  • Teele Kepler, MD · University of Tartu

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-01-31
Primary Completion
2018-02-08
Completion
2019-02-28

Countries

  • Estonia

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02689414 on ClinicalTrials.gov