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The Acute and Chronic Effects of Fruit Polyphenols on Chronic Disease (PPF)

NCT01729949 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 34

Last updated 2021-07-27

No results posted yet for this study

Summary

1. The primary objective is to determine the effect of fruit polyphenols on postprandial lipoprotein triglyceride metabolism after consumption a standard high carbohydrate/fat breakfast meal with a beverage rich in fruit-derived polyphenols compared to energy and macro-/micro-nutrient matched control beverage (acute, Part 1).
2. Secondary objectives are: 1)to assess the effects of consuming daily for 8 weeks (chronic, Part 2) a beverage rich in fruit polyphenols compared to an energy and macro-/micro- nutrient matched control beverage on fasting glucose, insulin, lipids and markers of oxidative stress; and 2) to assess the effects of these beverages on meal-related changes in metabolic and oxidative stress measures after 8 weeks daily consumption.

Conditions

Interventions

DIETARY_SUPPLEMENT

Active Treatment Beverage

Strawberry and Blackcurrent extract

DIETARY_SUPPLEMENT

Placebo Treatment Beverage

without active components

Sponsors & Collaborators

  • GlaxoSmithKline

    collaborator INDUSTRY

  • Clinical Nutrition Research Center, Illinois Institute of Technology

    lead INDUSTRY

Principal Investigators

  • Britt Burton-Freeman, Ph.D · Illinois Institute of Technology

  • Indika Edirisinghe, Ph.D · Illinois Instutute of Technology

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
40 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-12-01
Primary Completion
2014-03-20
Completion
2018-06-26

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01729949 on ClinicalTrials.gov