Effect of a Polyphenol-rich Food Supplement on Cognitive Function in Healthy Aging Adults

Summary

Several preliminary studies have shown that diet can have beneficial effects on cognitive decline. Among food shown to have such effects are some polyphenols from selected botanicals.

Preclinical studies have concluded that polyphenols play a role in moderation of oxidative stress and inflammation, increased neuronal signaling, and improved metabolic function among other effects. Noteworthy, a positive and statistically significant association between the midlife level of polyphenol intake and cognitive function assessed 13 years later was found in a cohort of 2574 adults.

Several mechanisms may be involved in these positive effects of food polyphenols on cognitive function in older adults: experimental studies suggest that polyphenols display neuroprotective effects, enhancement of the neuronal function, stimulation of brain flow and inducing neurogenesis, and might prevent age-related damage to the central nervous system through their antioxidant and anti-inflammatory activities.

Based on these promising results, a food supplement from botanicals offering complementary polyphenol profile was developed. This food supplement is aimed to aid at maintenance of cognitive function in older adults.

Conditions

• Healthy Elderly

Interventions

DIETARY_SUPPLEMENT

Polyphenol-rich extract

Two groups, each of 102 volunteers, are studied. For 24 weeks, one group of volunteers will consume the active product (polyphenol-rich extract) while the other one will consume the placebo product.

DIETARY_SUPPLEMENT

Placebo

The placebo is a capsule with same appearance and organoleptic properties as the active product, containing no active component. Two groups, each of 102 volunteers, are studied. For 24 weeks, one group of volunteers will consume the active product (polyphenol-rich extract) while the other one will consume the placebo product.

Sponsors & Collaborators

• Activ'inside

  collaborator INDUSTRY

• Atrium Innovations

  collaborator INDUSTRY

• Fruit d'Or

  collaborator UNKNOWN

• Laboratoire NutriNeuro Université de Bordeaux/INRA

  collaborator UNKNOWN

• NutraCanada

  collaborator UNKNOWN

• Laval University

  collaborator OTHER

• Neurophenols Consortium

  lead OTHER

Principal Investigators

• Carol Hudon, Ph.D. · Laval University

• Véronique Pallet, Ph.D. · Laboratoire NutriNeuro Université de Bordeaux/INRA

• Catherine Bégin, Ph.D. · Laval University

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

60 Years

Max Age

70 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2014-02-28

Primary Completion

2015-03-31

Completion

2015-03-31

Countries

• Canada
• France

Study Locations