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Biomarkers in Aortic Stenosis - B.A.S.S.

NCT01334801 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 378

Last updated 2022-05-05

No results posted yet for this study

Summary

This study is being done to determine whether or not new blood test(s) can determine the severity of heart conditions. Aortic stenosis, hypertrophic cardiomyopathy, mitral regurgitation, aortic regurgitation, artificial heart valve regurgitation or stenosis, and tricuspid valve regurgitation associated with pacemaker leads are the cardiac disorders under study. The blood tests involve analysis for von Willebrand Factor antigen and activity, von Willebrand Factor multimers, and brain natriuretic peptide (BNP) levels. The results of the blood tests will be compared to the information from the clinically-indicated echocardiogram and one blood test compared to another.

Conditions

  • Aortic Stenosis
  • Disorder of Prosthetic Cardiac Valve
  • Aortic Valve Insufficiency
  • Mitral Valve Insufficiency
  • Hypertrophic Cardiomyopathy
  • Tricuspid Valve Insufficiency

Interventions

PROCEDURE

Blood Draw

Two tubes of blood (about five tablespoons) will be drawn for research purposes, and these will be analyzed for the following tests: 1. BNP (Brain Natriuretic Peptide) 2. (PFA) Platelet Function Analyzer 100 3. von Willebrand Factor (vWF) antigen 4. (vWF) multimers 5. (vWF) \*activity by latex aggregation 6. Plasma stored for development of new testing approaches

Sponsors & Collaborators

Principal Investigators

  • Joseph L Blackshear, M.D. · Mayo Clinic

Eligibility

Min Age
21 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-07-31
Primary Completion
2020-01-31
Completion
2020-01-31

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01334801 on ClinicalTrials.gov