Pfizer is an American multinational pharmaceutical and biotechnology corporation headquartered in New York City. Founded in 1849, it develops and manufactures medicines and vaccines across multiple therapeutic areas.
The White House reports a 3.1% drop in prescription drug prices over the past year, the steepest decline since 1963, attributing it to President Trump's Most Favored Nation policies and TrumpRx discounts. Drugmakers like Pfizer have agreed to significant price cuts on several medications.
Valneva withdrew its U.S. BLA and IND for chikungunya vaccine Ixchiq after an FDA clinical hold tied to a serious adverse event. The company reported a wider FY2025 net loss of €115.2 million, while its Lyme vaccine VLA15 showed over 70% efficacy in Phase III.
Several drugmakers saw shares fall after earnings missed expectations. Alnylam's Amvuttra sales disappointed despite growth; Neurocrine's guidance underwhelmed; AbbVie's Imbruvica and Roche's Vabysmo fell short of consensus.
FDA approved Moderna's mFLUSIVA, the first mRNA-based flu vaccine for adults 50+. It was 27% more effective than standard flu shots in a large trial. The approval came after earlier FDA pushback.
Recent studies have uncovered new cancer therapeutic targets and strategies, including self-assembling antibody-drug conjugates, a dual-action metabolic drug, and a BRAF protein structure. Research also advanced on dendritic cell vaccines, the origins of a rare childhood leukemia, and cancer cachexia treatment.
China has become the dominant source of external drug innovation, with pharma licensing deals reaching $135.7 billion in 2025 and China developing 30% of the world's new innovative drugs. Meanwhile, India is expanding AI use in drug discovery and strengthening its CRDMO and IP infrastructure, though investment gaps persist.
Lawmakers opened national security probes into Merck, AbbVie and others over China drug trials. A survey finds China closing in on U.S. biotech leadership, and HHS launched clinical trial reforms to counter the rise.
Novartis AG is selling its 70.68% controlling stake in Novartis India to ChrysCapital for $175 million, triggering a mandatory open offer at INR 860.64 per share. Shares surged 20% as the Swiss drugmaker shifts investment to US manufacturing amid tariff risks.
A JAMA Oncology study finds breast cancer patients using complementary and alternative medicine face a higher risk of death. A new molecule SU212 shows promise against triple-negative breast cancer, and global breast cancer cases are projected to rise to 3.5 million by 2050.
Trump’s phased tariffs on medicines spur over $400 billion in US pharma investments. Indian generic makers face a 2028 deadline to adapt.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07779590 |
A Study to Learn About the Outcomes Between Study Medicines, Enzalutamide and Darolutamide Among Men With Metastatic Castration Sensitive Prostate Cancer (mCSPC) |
NOT_YET_RECRUITING | |
| NCT07772921 |
A Study to Learn About the Study Medicine Called Tilrekimig in People With Severe Asthma |
NOT_YET_RECRUITING | PHASE3 |
| NCT07768358 |
Tucatinib Continuation Study |
NOT_YET_RECRUITING | PHASE4 |
| NCT07768345 |
A Study to Learn About Revaccination With a Vaccine Called RSVpreF in Immunocompromised Adults |
NOT_YET_RECRUITING | PHASE3 |
| NCT07768163 |
A Study to Learn About the Safety of PENBRAYA During Pregnancy |
RECRUITING | |
| NCT07765888 |
A Study to Learn About the Study Medicine Called Tilrekimig in People With Moderate-to-Severe Eczema |
NOT_YET_RECRUITING | PHASE3 |
| NCT07754539 |
A Study to Evaluate 20vPnC in Healthy Chinese Infants |
RECRUITING | PHASE3 |
| NCT07754266 |
Headache Ear Auditory Dizziness Sinus (HEADS) Registry |
RECRUITING | |
| NCT07733765 |
A Study in Young People and Adults to Learn About the Medicine Ritlecitinib for Treatment of Patchy Hair Loss, Known by the Medical Term as Moderate Alopecia Areata |
NOT_YET_RECRUITING | PHASE3 |
| NCT07731139 |
A Study to Learn How Different Amounts of the Study Medicine Called PF-08642534 Are Tolerated and Act in the Body of People Who Have Obesity |
NOT_YET_RECRUITING | PHASE1 |
