Investigating the Link Between Type 2 Immunity and NAFLD in Human Obesity
NCT04232566 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 60
Last updated 2026-01-28
Summary
This study is being done to better understand the relationship between inflammation in adipose tissue (AT), abnormal deposition of fat around the liver and how this affects its appearance and function and ultimately insulin resistance.
Conditions
- Obesity, Morbid
- NASH - Nonalcoholic Steatohepatitis
- Chronic Inflammation
Interventions
- PROCEDURE
-
Bariatric surgery
Evaluate liver fibrosis by elastography before gastric bypass surgery.
Sponsors & Collaborators
- lead OTHER
Principal Investigators
-
Elena Anna O De Filippis · Mayo Clinic
Eligibility
- Min Age
- 30 Years
- Max Age
- 70 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2022-02-20
- Primary Completion
- 2025-12-31
- Completion
- 2027-12-30
Countries
- United States
Study Locations
More Related Trials
-
Technical Validation of MR Biomarkers of Obesity-Associated NAFLD
NCT03674528 ·Status: COMPLETED
-
Role of New Adipokines and Hepatokines in Prediction of Patients With Metabolic Syndrome or NAFLD
NCT02285218 ·Status: UNKNOWN
-
Nonalcoholic Fatty Liver Disease in Morbidly Obese Patients
NCT04059029 ·Status: UNKNOWN
-
Liver Health and Metabolic Function in People With Obesity
NCT03701828 ·Status: COMPLETED ·Phase: NA
-
Systemic and White Adipose Tissue Inflammatory Profile in Lean Versus Obese Individuals
NCT04078776 ·Status: COMPLETED
-
Obesity and Nonalcoholic Fatty Liver Disease
NCT00262964 ·Status: COMPLETED ·Phase: NA
-
Molecular, Cellular, and Genetic Characterization of Human Adipose Tissue and Its Role in Metabolism
NCT02692885 ·Status: RECRUITING
-
The Liver Health Study for Patients with NAFLD
NCT03151798 ·Status: COMPLETED ·Phase: NA
-
Palmitate Breath Test to Assess Fatty Acid Oxidation in Non Alcoholic Fatty Liver Disease (NAFLD)
NCT02363309 ·Status: COMPLETED
-
Characterization of Bile Acid Pathway in Obesity
NCT03341052 ·Status: COMPLETED ·Phase: NA
-
Liver Fat Content and Bariatric Surgery
NCT06064240 ·Status: UNKNOWN
-
Adaptive Immune Response in Visceral and Subcutaneous Fat: Role in Human Insulin Resistance
NCT04708535 ·Status: ENROLLING_BY_INVITATION
-
Fatty Liver Disease Collaborative Research in China
NCT02391168 ·Status: UNKNOWN
-
BeijngFH Health Cohort Study
NCT05546086 ·Status: RECRUITING
-
Inflammation Regulation in Obese Patients
NCT01561664 ·Status: COMPLETED ·Phase: NA
-
Altered Drug Disposition and Biomarkers for Diagnosis of Chronic Inflammatory Liver Disease
NCT01766960 ·Status: COMPLETED ·Phase: PHASE1
-
De Novo Lipogenesis in Severity of NAFLD
NCT03683589 ·Status: COMPLETED
-
Inflammation and Obesity-associated Disease
NCT02322073 ·Status: RECRUITING
-
Investigating Pathological Mechanisms in Non-alcoholic Fatty Liver Disease
NCT04141592 ·Status: RECRUITING
-
Adiponectin and Circulating Macrophage Phenotypes in Non-alcoholic Fatty Liver Disease (NAFLD)
NCT01472120 ·Status: UNKNOWN
-
A Study of Adipose Tissue in Adaptive Responses to Exercise
NCT06053125 ·Status: ACTIVE_NOT_RECRUITING ·Phase: NA
-
Evaluation of Systemic Microvascular Endothelial Function in Metabolically Healthy Obesity
NCT04233528 ·Status: COMPLETED ·Phase: NA
-
Intermittent Fasting for NAFLD in Adults
NCT04899102 ·Status: RECRUITING ·Phase: NA
-
Non-Alcoholic Fatty Liver Disease in a Saudi Cohort With Type 2 Diabetes Mellitus
NCT05697991 ·Status: RECRUITING
-
Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)
NCT06571474 ·Status: RECRUITING