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Effect of Arginine on Microcirculation in Patients With Diabetes

NCT00902616 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2013-11-27

No results posted yet for this study

Summary

Patients with diabetes have dysfunction of the lining of the arteries which lead to impaired circulation in the small blood vessels. This is thought to be secondary to reduced chemicals in the blood viz: nitric oxide. This chemical is derived from an amino acid (protein) L-arginine. Therefore, the researchers investigated whether giving patients L-arginine (versus dummy powder) would improve the blood flow in the small blood vessels in the lower limbs of patients with damage to their nerves (neuropathy).

Conditions

Interventions

DIETARY_SUPPLEMENT

L-arginine

3gm TDS for three months

DIETARY_SUPPLEMENT

Placebo Lactose powder

3gm TDS for 3 months

Sponsors & Collaborators

  • Tameside Hospital NHS Foundation Trust

    lead OTHER

Principal Investigators

  • Edward Jude, MD, MRCP · Tameside General Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
30 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2003-06-30
Primary Completion
2006-06-30
Completion
2006-06-30

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00902616 on ClinicalTrials.gov