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CALERIE: Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy

NCT00427193 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 238

Last updated 2022-03-16

Study results available
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Summary

The purpose of this study is to test the hypothesis that two years of sustained 25% caloric restriction (CR) in men age 21-50 (inclusive) and women age 21-47 (inclusive) will slow aging and protect against age-related disease processes.

Conditions

  • Aging

Interventions

BEHAVIORAL

Caloric Restriction (CR)

Participants follow a diet with 25% fewer calories than calculated at baseline over a period of 24 months

BEHAVIORAL

Control

Participants continue their current diet for 24 months

Sponsors & Collaborators

Principal Investigators

  • William Kraus, MD · Duke Clinical Research Institute

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
21 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2007-05-31
Primary Completion
2012-11-30
Completion
2012-11-30

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00427193 on ClinicalTrials.gov