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The Effect of Food Stimuli on the Calorie Restriction Response in Healthy Subjects

NCT01243879 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2020-02-21

No results posted yet for this study

Summary

Calorie restriction extends life span and prevents aging-related diseases in several species. Odorants from live yeast restrain the beneficial effects of calorie restriction in Drosophila Melanogaster. The investigators hypothesize that visual and odorous food stimuli impact the neuroendocrine and metabolic response to starvation in healthy humans.

In this randomized cross-over intervention study 12 healthy, young men will fast twice for 60-hours in the presence or absence of food-related visual and odorous stimuli. At baseline and on the last morning of each intervention an oral glucose tolerance test (OGTT) will be performed. During the OGTT blood is sampled and hypothalamic neuronal activity is measured by functional MRI.

Conditions

  • Calorie Restriction
  • Aging

Interventions

OTHER

No stimuli of food smell and vision

60 hours of starvation (fasting) in the presence or absence of visual and odorous food cues

OTHER

Stimuli of food smell and vision

60 hours of starvation (fasting) in the presence or absence of visual and odorous food cues

Sponsors & Collaborators

  • Center for Medical Systems Biology

    collaborator UNKNOWN

  • Roba Metals BV, IJsselstein

    collaborator UNKNOWN

  • Leiden University Medical Center

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2008-07-31
Primary Completion
2009-03-31
Completion
2009-03-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01243879 on ClinicalTrials.gov