Effects of Intensive Long-Term Vasodilation in Hypertensive Patients With Microvascular Angina Pectoris

Summary

The purpose of this study is to determine if long-term vasodilatory treatment is more effective than the standard treatment in hypertensive patients with microvascular angina pectoris

Conditions

• Microvascular Angina
• Hypertension

Interventions

DRUG

Lercanidipine

Individual titration, max. dose 20 mg OD for 8 months

DRUG

Valsartan

Individual titration, max. dose 160 mg OD for 8 months

DRUG

Nicorandil

Individual titration, max. dose 20 mg BD for 8 months

DRUG

Doxazosin

Individual titration, max. dose 4 mg OD for 8 months

DRUG

Moxonidin

Possible add-on therapy in case target blood pressure can not be reached with a combination of the other drugs in the Vasodilatory arm. Individual titration, max. dose 0,2 mg OD for 8 months

DRUG

Pindolol

Possible add-on therapy in case target blood pressure can not be reached with a combination of the other drugs in the Vasodilatory arm. Individual titration, max. dose 10 mg OD for 8 months

DRUG

Amiloride, hydrochlorothiazide

Possible add-on therapy in case target blood pressure can not be reached with a combination of the other drugs in the Vasodilatory arm. Individual titration, max. dose 1 tbl. OD for 8 months

Sponsors & Collaborators

• Danish Cardiovascular Research Academy

  collaborator UNKNOWN

• Danish Heart Foundation

  collaborator OTHER

• Novartis

  collaborator INDUSTRY

• University of Aarhus

  lead OTHER

Principal Investigators

• Michael N Præstholm, MD · University of Aarhus

• Kent L Christensen, MD, DrMSc · Aarhus Hospital, medical-cardiologic dept. A

• Won Yong Kim, MD, DrMSc · Skejby Hospital, cardiologic dept. B

• Hans Erik Bøtker, MD, DrMSc · Skejby Hospital, cardiologic dept. B

Study Design

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2007-01-31

Primary Completion

2008-12-31

Completion

2008-12-31

Countries

• Denmark

Study Locations