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A Prospective Study to Evaluate the Effect of Chronic Nitrate Therapy on Vasodilation Function in Coronary Heart Disease

NCT01430780 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 68

Last updated 2013-03-22

No results posted yet for this study

Summary

Basic studies has showed that sustained use of nitrates might associated with adverse effects on vascular function mediated by an increase in nitrate-induced oxidative stress. But it remains unclear whether oxidative stress increases with endothelial function impairment in patients with coronary artery disease (CAD) during administration of long-term oral nitrates. The investigators evaluated whether administration of long-term isosorbide mononitrate (ISMN) treatment was associated with oxidative stress increase and endothelial function impairment in patients with CAD.

Conditions

Interventions

DRUG

nitrate group

Isosorbide Mononitrate orally 20mg twice per day.

DRUG

control group

placebo

Sponsors & Collaborators

  • Zhejiang University

    lead OTHER

Principal Investigators

  • Jiangtao Lai, Doctor · Zhejiang University

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-08-31
Primary Completion
2013-12-31
Completion
2013-12-31

Countries

  • China

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01430780 on ClinicalTrials.gov