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Effect of Beta-blockers on Coronary Flow and Resistance in Patients With ANOCA

NCT06864234 · Status: RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 46

Last updated 2025-07-14

No results posted yet for this study

Summary

The goal of this clinical trial is to learn whether beta-blockers can improve coronary blood flow and reduce resistance in patients with angina and no obstructive coronary arteries (ANOCA).

The main questions it aims to answer are:

* Do beta-blockers improve coronary blood flow in patients with ANOCA?
* Do beta-blockers reduce coronary microvascular resistance in these patients?

Researchers will compare a beta-blocker to a placebo to see if the medication has measurable effects on coronary circulation.

Participants will:

* Receive a beta-blocker or a placebo
* Undergo specialized heart tests (such as coronary flow and resistance measurements) before and after treatment.

Conditions

  • Coronary Arterial Disease (CAD)
  • Angina (Stable)
  • Microvascular Circulation

Interventions

DRUG

Saline (NaCl)

IV 0.9% NaCl (5 ml)

DRUG

Metoprolol Tartrate

Metoprolol Tartrate (5 ml of 1 mg/ml solution for injection)

Sponsors & Collaborators

  • VZW Cardiovascular Research Center Aalst

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-07-03
Primary Completion
2025-12-31
Completion
2025-12-31

Countries

  • Belgium

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06864234 on ClinicalTrials.gov