Effects of Functional Ingredients in an Acute Metabolic Challenge Context

Summary

After an energy-rich meal the blood levels of glucose and lipids undergo a marked temporary increase, triggering a wave of oxidative stress due to the appearance of excess free radicals in adipose and muscle tissues. Elevated postprandial hypertriglyceridemia has been associated with increased risk of cardiovascular disease and type 2 diabetes. Hence, postprandial changes in different circulating biomarkers are potential predictors of cardiometabolic risk. In addition to the possibility of evaluating acute variations in metabolic risk markers in response to different types of fat, the metabolic challenge approach may serve as a challenge-meal background in order to reveal possible beneficial effects of specific food ingredients. In this study, circulating cardiometabolic disease-related biomarkers, including endotoxemia, will be assessed postprandially in search for beneficial actions of particular functional food ingredients consumed in combination with a high-fat meal.

Conditions

• Metabolic Syndrome

Interventions

OTHER

Reference breakfast

A high fat, high calorie breakfast

OTHER

Active Ingredient 1

A high fat, high calorie breakfast including the Active Ingredient 1

OTHER

Active Ingredient 2

A high fat, high calorie breakfast including the Active Ingredient 2

OTHER

Active Ingredient 3

A high fat, high calorie breakfast including the Active Ingredient 3

OTHER

Active Ingredient 4

A high fat, high calorie breakfast including the Active Ingredient 4

Sponsors & Collaborators

• Vinnova

  collaborator OTHER_GOV

• Antidiabetic Food Centre AFC

  collaborator UNKNOWN

• Lund University

  lead OTHER

Principal Investigators

• Juscelino Tovar, PhD · Lund University

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Model

CROSSOVER

Eligibility

Min Age

50 Years

Max Age

73 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2015-08-31

Primary Completion

2016-01-31

Completion

2016-07-31

Countries

• Sweden

Study Locations