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Time Course of Procalcitonin and C Reactive Protein in Septic Patients Under Treatment With Corticosteroids

NCT00141973 · Status: COMPLETED · Type: OBSERVATIONAL

Last updated 2008-05-14

No results posted yet for this study

Summary

A systemic treatment with corticosteroids has been advocated for various bacterial infectious diseases. Since the production of CRP is down-regulated by corticosteroids, a smaller increase or a more rapid decrease of this acute phase protein will:

1. suggest attenuated systemic inflammation, but
2. does not necessarily reflect adequate therapy of the infection.

For several reasons (good diagnostic tool for sepsis, induction not decreased by immunosuppressive therapy), procalcitonin could be a better marker for activity of sepsis in patients under corticosteroids. As this issue has not yet been examined the investigators will prospectively study the time-course of PTC and CRP in a well-defined septic patient group, that in adjunction to antibiotic therapy also received systemic corticosteroid treatment and compare it to a similar group without corticosteroid treatment.

Conditions

Sponsors & Collaborators

  • Brahms SA, D-16761 Hennigsdorf bei Berlin

    collaborator UNKNOWN

  • Ospedale Regionale Bellinzona e Valli

    lead OTHER

Principal Investigators

  • Andreas Perren, MD · Ospedale Regionale Bellinzona e Valli, CH-6500 Bellinzona

Eligibility

Min Age
50 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2004-11-30
Completion
2005-12-31

Countries

  • Switzerland

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00141973 on ClinicalTrials.gov