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Endothelium in Severe Sepsis

NCT00793442 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 910

Last updated 2024-10-29

No results posted yet for this study

Summary

The overall hypotheses of this project is that severe sepsis is associated with endothelial dysfunction; that endothelial dysfunction, in turn, is predictive of subsequent organ failure and death; and that protocolized resuscitation attenuates endothelial cell (EC) dysfunction and improves patient survival.

Conditions

  • Sepsis
  • Severe Sepsis
  • Septic Shock

Interventions

DIAGNOSTIC_TEST

Blood Collection and Assays

The researchers will sample blood upon enrollment, at 6 and 24 hours after the baseline sampling. The researchers will measure 6 different endothelial related biomarkers compromising different components of endothelial permeability and hemostasis.

Sponsors & Collaborators

Principal Investigators

  • Nathan I Shapiro, MD, MPH · Beth Israel Deaconess Medical Center

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-03-31
Primary Completion
2013-05-31
Completion
2013-05-31

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00793442 on ClinicalTrials.gov