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COronary Microcirculation and Troponin Elevation in Septic Shock

NCT06294730 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 62

Last updated 2025-06-29

No results posted yet for this study

Summary

Plasma cardiac troponin (cTn) elevation is an indicator of increased mortality in patients with sepsis yet the underlying cause of troponin elevation in sepsis is not known. The COMTESS study investigates whether elevated high-sensitive cardiac Troponin T (hs-cTnT) levels in hemodynamically unstable patients with sepsis can be explained by an underlying coronary artery disease or a process within the coronary microcirculation. Fifty patients with sepsis and with hs-cTnT elevation (\>15 ng/L) will undergo coronary angiography, including an assessment of coronary flow using a method called thermo-dilution to record the index of microcirculatory resistance (IMR) in the left anterior descending artery (LAD). The relationship between IMR and hs-cTnT will subsequently be analysed. It is important to identify the underlying causes of elevated cTn during sepsis to target further research with an aim to improve the survival in patients suffering from this condition.

Conditions

  • Sepsis
  • Myocardial Injury
  • Coronary Microvascular Dysfunction
  • Endothelial Dysfunction

Sponsors & Collaborators

Principal Investigators

  • Jonas Persson, MD, PhD · Karolinska Institutet Danderyd University Hospital

Eligibility

Min Age
40 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-06-13
Primary Completion
2024-12-20
Completion
2025-02-28

Countries

  • Sweden

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06294730 on ClinicalTrials.gov