Procalcitonin to Shorten Antibiotics Duration in ICU Patients

Summary

The trial is aimed to show that implementation of a procalcitonin-guided antibiotics algorithm may result in shortened antibiotics course in ICU sepsis patients without inferior outcome as compared to the conventional therapy

Conditions

• Sepsis

Interventions

BEHAVIORAL

Procalcitonin guided antibiotics treatment algorithm

Patients who will be randomized to arm 2 will receive antibiotics therapy with a duration based on procalcitonin measurement on day 5, 7 and 9.

BEHAVIORAL

Conventional treatment

Patients who will be randomized to arm 1 will receive antibiotic therapy with a duration based on conventional practice.

Sponsors & Collaborators

• Beijing Chao Yang Hospital

  collaborator OTHER

• Ruijin Hospital

  collaborator OTHER

• Shanghai Jiao Tong University School of Medicine

  collaborator OTHER

• Chongqing Medical University

  collaborator OTHER

• Tianjin Medical University General Hospital

  collaborator OTHER

• Chinese PLA General Hospital

  collaborator OTHER

• Xinjiang Medical University

  collaborator OTHER

• Princess Margaret Hospital, Hong Kong

  collaborator OTHER_GOV

• National Taiwan University Hospital

  lead OTHER

Principal Investigators

• Chien-Chang Lee, MD, MSc · National Taiwan University Hospital

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

20 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2011-06-30

Primary Completion

2012-12-31

Completion

2013-06-30

Countries

• China
• Hong Kong
• Taiwan

Study Locations