Functional Genomic Influences on Disease Progression and Outcome in Sepsis

Summary

The proposal is aimed at identifying genetic factors that determine the incidence and severity of, and the outcome from life-threatening infections (severe sepsis/septic shock) in patients admitted to High Dependency Units (HDUs) or Intensive Care Units (ICUs) with pneumonia which developed outside the hospital (community acquired pneumonia - CAP) or contamination of the abdominal cavity with faeces due to a leak in the bowel (faecal peritonitis). This will require the acquisition of a large, high quality resource of genetic material (DNA), plasma, urine, white blood cells and clinical information from well characterized groups of similar patients with, or at risk for, severe sepsis/septic shock. The principal objective is to perform studies which are sufficiently large to establish beyond doubt the influence of a series of selected "candidate" genes on the development, progress and outcome of sepsis.

Conditions

• Pneumonia
• Peritonitis

Sponsors & Collaborators

• Sainsbury Family Charitable Trusts

  collaborator OTHER

• Wellcome Trust

  collaborator OTHER

• Queen Mary University of London

  collaborator OTHER

• Barts and the London School of Medicine and Dentistry

  collaborator OTHER

• University of Oxford

  lead OTHER

Principal Investigators

• Achyut Guleri, MD · Blackpool Victoria Hospital

• Shond Laha, MD · Royal Preston Hospital

• Christopher S Garrard, MD PhD · University of Oxford, UK

• Charles J Hinds, MD · Queen Mary College, University of London, UK

• Simon Baudouin, MD · Royal Victoria Infirmary and Freeman Hospital, Newcastle, UK

• David Higgins, MD · Southend General Hospital, Southend, UK.

• Richard Venn, MD · Worthing and Southlands Hospitals NHS Trust, Worthing, UK.

• David Watson, MD · Homerton University Hospital, London, UK.

• Atul Kapila, MD · Royal Berkshire Hospital, Reading, UK.

• Simon Fletcher, MD · Norfolk and Norwich University Hospitals, Norwich, UK.

• Andrew Johnston, MD · Addenbrooke's Hospital, Cambridge, UK.

• Julian Bion, Professor · Queen Elizabeth Hospital, Birmingham, UK.

• Gary Mills, MD · Royal Halamshire Hospital, Sheffield, UK.

• Stephen Bonner, MD · James Cook University Hospital, Middlesborough, UK.

• Mark Garfield, MD · The Ipswich Hospital, Ipswich, UK.

• Ronald Baillie, MD · Antrim Hospital, Antrim, Northern Ireland.

• George Findlay, MD · University Hospital of Wales, Cardiff,UK.

• Geoffrey Bellingan, MD · UCLH Middlesex Hospital, London, UK.

• Tony Gordon, MD · Charing Cross Hospital, London, UK.

• Michelle Hayes, MD · Chelsea and Westminster Hospital, London, UK.

• Dilshan Arawwawala, MD · Broomfield Hospital, Chelmsford, UK.

• Andrew Bentley, MD · Wythenshawe Hospital, Manchester, UK.

• Gareth Thomas, MD · Hope Hospital, Manchester, UK.

• Julian Knight, MD · Wellcome Trust

• Jonathan Thompson, MD · University Hospitals, Leicester

• Jasmeet Soar, MD · Frenchay Hospital and Southmead Hospital, Bristol

• Phil Watt, MD · Kettering General Hospital

• Anton Krige, MD · Royal Blackburn Hospital

• Ian Smith, MD · Castle Hill Hospital and Hull Royal Infirmary

• Stephen Brett, MD · Hammersmith Hospitals NHS Trust

• Jeronimo Moreno Cuesta, MD · North Middlesex University Hospital

• Pyda Venkatesh, MD · Coventry University Hospital

• Peter Hall, MD · Huddersfield Royal Infirmary and Calderdale Royal Hospital

• Martin Kuper, MD · The WhittingtonHospital, London. UK

• Sia Pesian, MD · Manor Hospital, Walsall. UK

• Andrew Timmins, MD · Colchester Hospital, Colchester . UK

• Stephen Drage, MD · Royal Sussex County Hospital

• Martin Stotz, MD · St. Mary's Hospital, London, UK

• Mark Blunt, MD · Queen Elizabeth Hospital, King's Lynn. UK

• Nigel Webster, Professor · Aberdeen Royal Infirmary

• Jane Minton, MD · St James Hospital, Leeds. UK

• Matt Oram, MD · Cheltenham General Hospital, Cheltenham. UK

• Ingrid Krupe, MD · Lewisham Hospital

• Abhiram Mallick, MD · Leeds General Infirmary, Leeds. UK

• Samuel Pambakian, MD · Frimley Park Hospital, Frimley. UK

• Malcolm Watters, MD · Great Western Hospital, Swindon. UK

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2005-09-30

Primary Completion

2017-12-31

Completion

2017-12-31

Countries

• United Kingdom

Study Locations