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Molecular Biomarkers for Sepsis

NCT04280354 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 3

Last updated 2024-05-09

No results posted yet for this study

Summary

This multi-center observational case-control study in Intensive Care Unit (ICU) patients is to identify novel biomarkers allowing to recognize severe community acquired pneumonia (sCAP) -associated sepsis at an earlier stage and predict sepsis-related mortality. Patients with sCAP (cases) will be profoundly characterized over time regarding the development of sepsis and compared with control patients. The mechanisms and influencing factors on the clinical course will be explored with most modern -omics technologies allowing a detailed characterisation. These data will be analysed using machine learning algorithms and multi-dimensional mathematical models.

Conditions

  • Sepsis
  • Severe Community-acquired Pneumonia (sCAP)
  • Infection, Bacterial

Interventions

OTHER

compare data patterns by data-driven algorithms to determine sepsis

compare data patterns by data-driven algorithms including machine learning and multi-dimensional modelling to reliably determine sepsis

OTHER

compare data patterns by data-driven algorithms to predict sepsis-related mortality

compare data patterns by data-driven algorithms including machine learning and multi-dimensional modelling to to predict sepsis-related mortality

Sponsors & Collaborators

  • Swiss Personalized Health Network (SPHN)

    collaborator UNKNOWN

  • Personalized Health and Related Technologies (PHRT) initiative of ETH Zürich

    collaborator UNKNOWN

  • University Hospital, Basel, Switzerland

    lead OTHER

Principal Investigators

  • Adrian Egli, PD Dr. · Clinical Microbiology, University Hospital Basel

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-02-16
Primary Completion
2022-07-31
Completion
2022-07-31

Countries

  • Switzerland

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04280354 on ClinicalTrials.gov