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Regulation of Endocrine, Metabolic, Immune and Bioenergetic Responses in Sepsis

NCT00187824 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2005-09-16

No results posted yet for this study

Summary

The hypothesis of this study is that bioenergetic failure in human sepsis, related to endocrine, metabolic and mitochondrial dysfunction, is a major determinant of defective host immune responses, increasing disease severity and risk of death. The objectives of this study are to examine the relationship between the severity of illness, and temporal changes in the activity of endocrine, metabolic and bioenergetic pathways, and consequent immune dysfunction in critically ill patients with sepsis and multiple organ failure in the Intensive Care Unit.

Conditions

Sponsors & Collaborators

  • University College London Hospitals

    lead OTHER

Principal Investigators

  • Mervyn Singer, MBBS MD FRCP · UCL/UCLH

  • Geoff Bellingan, PhD FRCP · UCL/UCLH

  • Paul Glynne, PhD FRCP · UCL/UCLH

Eligibility

Min Age
16 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2004-07-31
Completion
2007-08-31

Countries

  • United Kingdom

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00187824 on ClinicalTrials.gov