Risk Factors for Adverse Outcomes in Sepsis
NCT06541600 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 567
Last updated 2026-05-20
Summary
This multi-phase prospective study utilized Data-Independent Acquisition proteomics on a nested subset (15 SIC vs. 15 matched sepsis) to map early molecular alterations. Guided by gene-set enrichment evidence of extracellular matrix (ECM) disruption as a pathway-derived biomarker. Admission matrix metalloproteinase-3 was validated in 567 critically ill patients (417 sepsis, 150 non-septic controls) across three hospital campuses.
Conditions
Sponsors & Collaborators
-
Qin Zhang
lead OTHER
Principal Investigators
-
QIN Zhang, phd · Tongji Hospital
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2017-06-01
- Primary Completion
- 2024-10-14
- Completion
- 2024-10-14
Countries
- China
Study Locations
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