Multiple Therapies in Treating Patients With Advanced Neuroblastoma

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells. Monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. Radiation therapy uses high-energy x-rays to damage tumor cells. Biological therapies use different ways to stimulate the immune system and stop cancer cell from growing. Combining different types of therapies may kill more tumor cells.

PURPOSE: Phase II trial to study the effectiveness of combining chemotherapy, monoclonal antibody therapy, surgery, peripheral stem cell transplantation, radiation therapy, and biological therapy in treating patients who have advanced neuroblastoma.

Conditions

• Neuroblastoma

Interventions

BIOLOGICAL

filgrastim

BIOLOGICAL

monoclonal antibody 3F8

BIOLOGICAL

sargramostim

DRUG

carboplatin

DRUG

cisplatin

DRUG

cyclophosphamide

DRUG

doxorubicin hydrochloride

DRUG

etoposide

DRUG

isotretinoin

DRUG

thiotepa

DRUG

topotecan hydrochloride

DRUG

vincristine sulfate

PROCEDURE

autologous bone marrow transplantation

PROCEDURE

bone marrow ablation with stem cell support

PROCEDURE

conventional surgery

PROCEDURE

drug resistance inhibition treatment

PROCEDURE

peripheral blood stem cell transplantation

PROCEDURE

syngeneic bone marrow transplantation

RADIATION

radiation therapy

Sponsors & Collaborators

• National Cancer Institute (NCI)

  collaborator NIH

• Memorial Sloan Kettering Cancer Center

  lead OTHER

Principal Investigators

• Nai-Kong V. Cheung, MD, PhD · Memorial Sloan Kettering Cancer Center

Study Design

Purpose

TREATMENT

Masking

NONE

Eligibility

Max Age

50 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2000-06-30

Primary Completion

2007-01-31

Completion

2007-01-31

Countries

• United States

Study Locations