Also known as: crack cocaine
Cocaine is a tropane alkaloid with stimulant and local anesthetic properties. Although widely known for illicit use, pharmaceutical cocaine formulations are used medically in limited settings such as topical anesthesia. In the U.S., cocaine-containing products are controlled Schedule II substances.
Drug-soaked paper has become the most commonly found drug in Ohio prisons and was tied to at least 13 fatal K2 overdoses in 2024. Convictions in the state’s largest prison drug conspiracy case detailed how the paper was smuggled and sold.
Police in Karachi, Kentucky and Indiana arrested three suspects in separate drug investigations involving alleged trafficking in Ice, methamphetamine and cocaine. One case involved a controlled purchase, while another led to the seizure of nearly 60 grams of cocaine and a firearm.
More than 2,700 drivers were arrested for drug-related offences in January as authorities expanded roadside inspections and medical testing. Separate road safety checks in Keighley recorded 17 offences, including one drug-driving arrest.
Laurel police said four people were arrested and one more is wanted after a two-month-long drug investigation. Officers said they found heroin, cocaine, crack cocaine and a .38 caliber handgun at a Laurel apartment complex home.
New Zealand police arrested 11 people and seized drugs, cash, and firearms after uncovering a dark web drug import network, while Canadian police made a separate bust seizing cocaine, fentanyl, and methamphetamine. The New Zealand operation involved international cooperation and intercepted over 200kg of drugs at borders. The busts come as New Zealand data shows record-breaking cocaine consumption nationwide.
A study of over 600,000 patients reveals GLP-1 drugs may reduce addiction across multiple substances, with 50% fewer substance-related deaths and significant reductions in overdoses and hospitalizations. The drugs work by dampening dopamine signaling in brain reward centers. Researchers are exploring broader applications for these medications beyond diabetes and obesity treatment.
A months-long drug investigation in North Carolina led to four arrests and over 70 felony charges, with seizures including firearms and 120 grams of cocaine and methamphetamine. Separately, a traffic stop revealed cocaine, marijuana, and a firearm, highlighting ongoing regional drug activity. Law enforcement officials note challenges from differing state marijuana laws and increasing drug-related incidents.
Delaware State Police arrested a North Carolina man and seized 2.3 kilograms of cocaine during a traffic stop on I-95. The suspect faces multiple felony drug charges and is being held on $120,801 cash bond. Separate drug investigations in West Virginia and Ohio also resulted in arrests and seizures of fentanyl, methamphetamine, firearms, and child pornography.
DEA and New York authorities seized over 8,800 counterfeit fentanyl pills and 891 grams of cocaine in Brooklyn, arresting one suspect. In a separate operation, agents recovered 20 pounds of methamphetamine and $50,000 in cash. The busts are part of efforts to disrupt synthetic drug shipments into New York City.
A Wisconsin man faces over a dozen felony charges for allegedly growing marijuana and possessing firearms near a Girl Scout camp, while a Massachusetts man was arrested on drug and firearm charges. The Wisconsin suspect could face over 160 years in prison if convicted on all counts.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT05809453 |
Intranasal Cocaine and Temperature Regulation During Exercise |
COMPLETED | PHASE1/PHASE2 |
| NCT05019430 |
Cocaine and Zolmitriptan |
COMPLETED | EARLY_PHASE1 |
| NCT03954938 |
Behavioral Effects of Drugs (Inpatient): 38 |
TERMINATED | EARLY_PHASE1 |
| NCT03937986 |
Suvorexant and Cocaine |
COMPLETED | EARLY_PHASE1 |
| NCT03519022 |
Behavioral Effects of Drugs: Inpatient (35) |
COMPLETED | EARLY_PHASE1 |
| NCT02538744 |
Complementary Combination Therapy for Cocaine Dependence |
COMPLETED | PHASE1 |
| NCT02522325 |
Reinforcing Effects of Cocaine During Phendimetrazine Maintenance |
COMPLETED | PHASE1 |
| NCT02383043 |
Impact of Sustained Release d-Amphetamine on Choice Between Cocaine and a Non-Drug Reinforcer |
COMPLETED | EARLY_PHASE1 |
| NCT02239913 |
Topiramate-Phentermine Combinations for Cocaine Dependence |
COMPLETED | PHASE1 |
| NCT02233647 |
Phendimetrazine and Cocaine |
COMPLETED | EARLY_PHASE1 |
