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Topiramate-Phentermine Combinations for Cocaine Dependence

NCT02239913 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 38

Last updated 2019-11-27

No results posted yet for this study

Summary

This study will determine the influence of topiramate (Topamax®) and phentermine (Adipex®), alone and in combination, on the reinforcing, subjective and physiological effects of cocaine.

Conditions

  • Cocaine Use Disorder

Interventions

DRUG

Cocaine

The pharmacodynamic effects of cocaine will be determined during maintenance on placebo and topiramate.

DRUG

Placebo

The pharmacodynamic effects of placebo will be determined during maintenance on placebo and topiramate.

DRUG

Phentermine

The pharmacodynamic effects of phentermine maintenance will be determined during maintenance on placebo and topiramate.

DRUG

Topiramate

The pharmacodynamic effects of chronic topiramate will be determined.

Sponsors & Collaborators

  • National Institute on Drug Abuse (NIDA)

    collaborator NIH

  • University of Kentucky

    lead OTHER

Principal Investigators

  • Craig R Rush, Ph.D. · University of Kentucky

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
FACTORIAL

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-09-30
Primary Completion
2019-09-30
Completion
2019-09-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02239913 on ClinicalTrials.gov