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Clinical Trials

NCT02888743 | ACTIVE_NOT_RECRUITING | PHASE2
110 participants

Durvalumab and Tremelimumab With or Without High or Low-Dose Radiation Therapy in Treating Patients With Metastatic Colorectal or Non-small Cell Lung Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2017-08-14
Completion:
2023-12-31
Conditions
  • Metastatic Colorectal Carcinoma
  • Metastatic Lung Non-Small Cell Carcinoma
  • Stage IV Colorectal Cancer AJCC v7
  • Stage IV Lung Non-Small Cell Cancer AJCC v7
  • Stage IVA Colorectal Cancer AJCC v7
  • Stage IVB Colorectal Cancer AJCC v7
Interventions
  • BIOLOGICAL
  • RADIATION
Results Available
NCT02883062 | ACTIVE_NOT_RECRUITING | PHASE2
67 participants

Carboplatin and Paclitaxel With or Without Atezolizumab Before Surgery in Treating Patients With Newly Diagnosed, Stage II-III Triple-Negative Breast Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2017-08-02
Completion:
2019-12-18
Conditions
  • Invasive Breast Carcinoma
  • Stage II Breast Cancer AJCC v6 and v7
  • Stage III Breast Cancer AJCC v7
  • Triple-Negative Breast Carcinoma
Interventions
  • DRUG
  • PROCEDURE
Results Available
NCT02627443 | ACTIVE_NOT_RECRUITING | PHASE1
35 participants

Carboplatin, Gemcitabine Hydrochloride, and Berzosertib in Treating Patients With Recurrent and Metastatic Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2017-05-16
Completion:
2024-10-04
Conditions
  • Metastatic Fallopian Tube Carcinoma
  • Metastatic Ovarian Carcinoma
  • Metastatic Primary Peritoneal Carcinoma
  • Ovarian Endometrioid Tumor
  • Ovarian High Grade Serous Adenocarcinoma
  • Platinum-Sensitive Ovarian Carcinoma
  • Recurrent Fallopian Tube Carcinoma
  • Recurrent Ovarian Carcinoma
  • Recurrent Primary Peritoneal Carcinoma
  • Stage IV Fallopian Tube Cancer AJCC v6 and v7
  • Stage IV Ovarian Cancer AJCC v6 and v7
  • Stage IV Primary Peritoneal Cancer AJCC v7
Interventions
  • DRUG
  • OTHER
Results Available
NCT02595931 | ACTIVE_NOT_RECRUITING | PHASE1
66 participants

M6620 and Irinotecan Hydrochloride in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2016-07-22
Completion:
2023-03-07
Conditions
  • Metastatic Colorectal Carcinoma
  • Metastatic Lung Small Cell Carcinoma
  • Metastatic Malignant Solid Neoplasm
  • Metastatic Pancreatic Carcinoma
  • Refractory Colorectal Carcinoma
  • Refractory Lung Small Cell Carcinoma
  • Refractory Malignant Solid Neoplasm
  • Refractory Pancreatic Carcinoma
  • Stage III Colorectal Cancer AJCC v8
  • Stage III Lung Cancer AJCC v8
  • Stage III Pancreatic Cancer AJCC v8
  • Stage IV Colorectal Cancer AJCC v8
  • Stage IV Lung Cancer AJCC v8
  • Stage IV Pancreatic Cancer AJCC v8
  • Unresectable Colorectal Carcinoma
  • Unresectable Lung Small Cell Carcinoma
  • Unresectable Malignant Solid Neoplasm
  • Unresectable Pancreatic Carcinoma
Interventions
  • DRUG
  • PROCEDURE
No Results Yet
NCT02595879 | ACTIVE_NOT_RECRUITING | PHASE1
21 participants

Triapine With Chemotherapy and Radiation Therapy in Treating Patients With IB2-IVA Cervical or Vaginal Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2019-09-18
Completion:
2023-06-04
Conditions
  • Advanced Cervical Adenocarcinoma
  • Advanced Cervical Adenosquamous Carcinoma
  • Advanced Cervical Squamous Cell Carcinoma
  • Advanced Vaginal Adenocarcinoma
  • Advanced Vaginal Adenosquamous Carcinoma
  • Advanced Vaginal Squamous Cell Carcinoma
  • Stage IB2 Cervical Cancer AJCC v6 and v7
  • Stage II Cervical Cancer AJCC v7
  • Stage II Vaginal Cancer AJCC v6 and v7
  • Stage III Vaginal Cancer AJCC v6 and v7
  • Stage IIIB Cervical Cancer AJCC v6 and v7
  • Stage IVA Cervical Cancer AJCC v6 and v7
  • Stage IVA Vaginal Cancer AJCC v6 and v7
Interventions
  • PROCEDURE
  • DRUG
  • RADIATION
  • OTHER
Results Available
NCT02567435 | ACTIVE_NOT_RECRUITING | PHASE3
325 participants

Combination Chemotherapy With or Without Temsirolimus in Treating Patients With Intermediate Risk Rhabdomyosarcoma

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2016-06-01
Completion:
2023-06-30
Conditions
  • Alveolar Rhabdomyosarcoma
  • Botryoid-Type Embryonal Rhabdomyosarcoma
  • Embryonal Rhabdomyosarcoma
  • Rhabdomyosarcoma
  • Sclerosing Rhabdomyosarcoma
  • Spindle Cell Rhabdomyosarcoma
Interventions
  • OTHER
  • RADIATION
  • DRUG
  • BIOLOGICAL
Results Available
NCT02567422 | ACTIVE_NOT_RECRUITING | PHASE1
43 participants

Testing the Addition of M6620 (VX-970, Berzosertib) to Usual Chemotherapy and Radiation for Head and Neck Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2017-04-17
Completion:
2023-12-31
Conditions
  • Head and Neck Carcinoma of Unknown Primary
  • Head and Neck Squamous Cell Carcinoma
  • Stage III Hypopharyngeal Squamous Cell Carcinoma AJCC v7
  • Stage III Laryngeal Squamous Cell Carcinoma AJCC v6 and v7
  • Stage III Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7
  • Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7
  • Stage III Sinonasal Squamous Cell Carcinoma AJCC v6 and v7
  • Stage IV Hypopharyngeal Squamous Cell Carcinoma AJCC v7
  • Stage IV Laryngeal Squamous Cell Carcinoma AJCC v7
  • Stage IV Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7
  • Stage IV Oropharyngeal Squamous Cell Carcinoma AJCC v7
  • Stage IV Sinonasal Squamous Cell Carcinoma AJCC v7
Interventions
  • DRUG
  • PROCEDURE
  • OTHER
  • RADIATION
Results Available
NCT02535312 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
30 participants

Methoxyamine, Cisplatin, and Pemetrexed Disodium in Treating Patients With Advanced Solid Tumors or Mesothelioma That Cannot Be Removed by Surgery or Mesothelioma That Is Refractory to Pemetrexed Disodium and Cisplatin or Carboplatin

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2016-03-08
Completion:
2022-12-31
Conditions
  • Advanced Malignant Solid Neoplasm
  • Advanced Peritoneal Malignant Mesothelioma
  • Advanced Pleural Malignant Mesothelioma
  • Recurrent Peritoneal Malignant Mesothelioma
  • Recurrent Pleural Malignant Mesothelioma
  • Refractory Malignant Solid Neoplasm
  • Unresectable Solid Neoplasm
Interventions
  • DRUG
Results Available
NCT02496663 | ACTIVE_NOT_RECRUITING | PHASE1
138 participants

Osimertinib and Necitumumab in Treating Patients With EGFR-Mutant Stage IV or Recurrent Non-small Cell Lung Cancer Who Have Progressed on a Previous EGFR Tyrosine Kinase Inhibitor

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2016-05-11
Completion:
2027-06-30
Conditions
  • Metastatic Lung Non-Small Cell Carcinoma
  • Recurrent Lung Non-Small Cell Carcinoma
  • Stage IV Lung Cancer AJCC v8
Interventions
  • PROCEDURE
  • BIOLOGICAL
  • DRUG
No Results Yet
NCT02453620 | ACTIVE_NOT_RECRUITING | PHASE1
57 participants

Entinostat, Nivolumab, and Ipilimumab in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery or Locally Advanced or Metastatic HER2-Negative Breast Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2016-02-12
Completion:
2021-04-22
Conditions
  • Anatomic Stage III Breast Cancer AJCC v8
  • Anatomic Stage IV Breast Cancer AJCC v8
  • Breast Adenocarcinoma
  • Invasive Breast Carcinoma
  • Malignant Solid Neoplasm
Interventions
  • PROCEDURE
  • OTHER
  • DRUG
  • BIOLOGICAL
No Results Yet
NCT02446600 | ACTIVE_NOT_RECRUITING | PHASE3
579 participants

Testing the Use of A Single Drug (Olaparib) or the Combination of Two Drugs (Cediranib and Olaparib) Compared to the Usual Chemotherapy for Women With Platinum Sensitive Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2016-03-28
Completion:
2020-02-23
Conditions
  • Fallopian Tube Clear Cell Adenocarcinoma
  • Fallopian Tube Transitional Cell Carcinoma
  • Fallopian Tube Undifferentiated Carcinoma
  • Ovarian Clear Cell Adenocarcinoma
  • Ovarian Endometrioid Tumor
  • Ovarian Seromucinous Carcinoma
  • Ovarian Serous Tumor
  • Ovarian Transitional Cell Carcinoma
  • Ovarian Undifferentiated Carcinoma
  • Recurrent Fallopian Tube Carcinoma
  • Recurrent Ovarian Carcinoma
  • Recurrent Ovarian Endometrioid Adenocarcinoma
  • Recurrent Primary Peritoneal Carcinoma
Interventions
  • PROCEDURE
  • DRUG
  • OTHER
Results Available
NCT02425345 | COMPLETED | NA
49331 participants

Women's Health Initiative Strong and Healthy Study

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2015-04-02
Completion:
2024-12-31
Conditions
  • Myocardial Infarction
  • Stroke
  • Cardiovascular Mortality
  • Hip Fractures
  • Falls
  • Mortality
  • Venous Thromboembolic Event
  • Peripheral Artery Disease
  • Physical Function
  • Coronary Revascularization
  • Mobility and Independence
  • Clinical (Non-hip) Fractures
  • Sleep
  • Depressive Symptoms
Interventions
  • BEHAVIORAL
Results Available
NCT02345265 | ACTIVE_NOT_RECRUITING | PHASE2
70 participants

Testing the Combination of the Study Drugs Cediranib and Olaparib in Recurrent Ovarian Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2016-05-23
Completion:
2022-07-07
Conditions
  • Fallopian Tube Carcinoma
  • Fallopian Tube Endometrioid Adenocarcinoma
  • Fallopian Tube Serous Adenocarcinoma
  • Ovarian Carcinoma
  • Ovarian High Grade Endometrioid Adenocarcinoma
  • Ovarian High Grade Serous Adenocarcinoma
  • Primary Peritoneal Carcinoma
  • Primary Peritoneal Endometrioid Adenocarcinoma
  • Primary Peritoneal Serous Adenocarcinoma
Interventions
  • PROCEDURE
  • DRUG
  • OTHER
Results Available
NCT02101775 | ACTIVE_NOT_RECRUITING | PHASE2
124 participants

Gemcitabine Hydrochloride With or Without WEE1 Inhibitor MK-1775 in Treating Patients With Recurrent Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2014-07-21
Completion:
2022-02-03
Conditions
  • Ovarian Brenner Tumor
  • Ovarian Clear Cell Cystadenocarcinoma
  • Ovarian Endometrioid Adenocarcinoma
  • Ovarian Malignant Mixed Mesodermal (Mullerian) Tumor
  • Ovarian Mucinous Cystadenocarcinoma
  • Ovarian Seromucinous Carcinoma
  • Ovarian Serous Cystadenocarcinoma
  • Ovarian Serous Surface Papillary Adenocarcinoma
  • Ovarian Undifferentiated Carcinoma
  • Recurrent Fallopian Tube Carcinoma
  • Recurrent Ovarian Carcinoma
  • Recurrent Primary Peritoneal Carcinoma
Interventions
  • DRUG
  • OTHER
Results Available
NCT01804686 | RECRUITING | PHASE3
700 participants

A Long-term Extension Study of PCI-32765 (Ibrutinib)

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2013-09-09
Completion:
2026-12-31
Conditions
  • Chronic Lymphocytic Leukemia
  • Small Lymphocytic Lymphoma
  • Mantle Cell Lymphoma
  • Follicular Lymphoma
  • Diffuse Large B-cell Lymphoma
  • Waldenstrom Macroglobulinemia
  • Chronic Graft Versus Host Disease
Interventions
  • DRUG
No Results Yet
NCT01522976 | ACTIVE_NOT_RECRUITING | PHASE2
282 participants

Azacitidine With or Without Lenalidomide or Vorinostat in Treating Patients With Higher-Risk Myelodysplastic Syndromes or Chronic Myelomonocytic Leukemia

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2012-03-01
Completion:
2015-06-01
Conditions
  • Chronic Myelomonocytic Leukemia
  • Chronic Myelomonocytic Leukemia-1
  • Chronic Myelomonocytic Leukemia-2
  • Myelodysplastic Syndrome
  • Myelodysplastic Syndrome With Excess Blasts
  • Myelodysplastic Syndrome With Excess Blasts-1
  • Myelodysplastic Syndrome/Acute Myeloid Leukemia
Interventions
  • DRUG
  • OTHER
Results Available
NCT01366144 | ACTIVE_NOT_RECRUITING | PHASE1
94 participants

Veliparib, Paclitaxel, and Carboplatin in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery and Liver or Kidney Dysfunction

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2011-06-20
Completion:
2017-11-10
Conditions
  • Breast Carcinoma
  • Carcinoma of Unknown Primary
  • Endometrial Carcinoma
  • Esophageal Carcinoma
  • Liver Failure
  • Lung Carcinoma
  • Malignant Head and Neck Neoplasm
  • Malignant Testicular Neoplasm
  • Melanoma
  • Metastatic Malignant Solid Neoplasm
  • Ovarian Carcinoma
  • Renal Failure
  • Unresectable Malignant Neoplasm
  • Urothelial Carcinoma
Interventions
  • DRUG
  • OTHER
No Results Yet
NCT01142388 | ACTIVE_NOT_RECRUITING | PHASE2
94 participants

Paclitaxel With or Without Cixutumumab as Second-Line Therapy in Treating Patients With Metastatic Esophageal Cancer or Gastroesophageal Junction Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2010-09-21
Completion:
2014-07-15
Conditions
  • Metastatic Esophageal Adenocarcinoma
  • Metastatic Esophageal Squamous Cell Carcinoma
  • Metastatic Gastroesophageal Junction Adenocarcinoma
  • Recurrent Esophageal Adenocarcinoma
  • Recurrent Esophageal Carcinoma
  • Recurrent Esophageal Squamous Cell Carcinoma
  • Recurrent Gastroesophageal Junction Adenocarcinoma
  • Stage IV Esophageal Cancer AJCC v7
Interventions
  • BIOLOGICAL
  • OTHER
  • DRUG
Results Available
NCT01134614 | ACTIVE_NOT_RECRUITING | PHASE2
245 participants

Ipilimumab With or Without Sargramostim in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2010-12-28
Completion:
2013-02-15
Conditions
  • Advanced Melanoma
  • Metastatic Melanoma
  • Recurrent Melanoma
  • Stage III Cutaneous Melanoma AJCC v7
  • Stage IIIA Cutaneous Melanoma AJCC v7
  • Stage IIIB Cutaneous Melanoma AJCC v7
  • Stage IIIC Cutaneous Melanoma AJCC v7
  • Stage IV Cutaneous Melanoma AJCC v6 and v7
  • Unresectable Melanoma
Interventions
  • BIOLOGICAL
Results Available
NCT01012817 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
88 participants

Veliparib and Topotecan Hydrochloride in Treating Patients With Solid Tumors, Relapsed or Refractory Ovarian Cancer, or Primary Peritoneal Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2009-11-03
Completion:
2019-01-13
Conditions
  • Metastatic Malignant Solid Neoplasm
  • Recurrent Fallopian Tube Carcinoma
  • Recurrent Ovarian Carcinoma
  • Recurrent Primary Peritoneal Carcinoma
  • Unresectable Solid Neoplasm
Interventions
  • OTHER
  • DRUG
Results Available
NCT00977574 | ACTIVE_NOT_RECRUITING | PHASE2
349 participants

Paclitaxel, Carboplatin, and Bevacizumab or Paclitaxel, Carboplatin, and Temsirolimus or Ixabepilone, Carboplatin, and Bevacizumab in Treating Patients With Stage III, Stage IV, or Recurrent Endometrial Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2009-09-14
Completion:
2015-01-31
Conditions
  • Endometrial Adenocarcinoma
  • Endometrial Adenosquamous Carcinoma
  • Endometrial Clear Cell Adenocarcinoma
  • Endometrial Serous Adenocarcinoma
  • Recurrent Malignant Uterine Corpus Neoplasm
  • Stage IIIA Uterine Corpus Carcinoma or Carcinosarcoma by AJCC v7 Stage
  • Stage IIIB Uterine Corpus Carcinoma or Carcinosarcoma by AJCC v7 Stage
  • Stage IIIC Uterine Corpus Carcinoma or Carcinosarcoma by AJCC v7 Stage
  • Stage IVA Uterine Corpus Carcinoma or Carcinosarcoma by AJCC v7 Stage
  • Stage IVB Uterine Corpus Carcinoma or Carcinosarcoma by AJCC v7 Stage
Interventions
  • BIOLOGICAL
  • DRUG
  • OTHER
Results Available
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