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Effect of Guanfacine on Opioid-induced Hyperalgesia (OIH) and Tolerance

NCT01681264 · Status: TERMINATED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 137

Last updated 2026-04-24

No results posted yet for this study

Summary

Dual medication (guanfacine and morphine) as a standard treatment for chronic pain.

Conditions

Interventions

DRUG

Morphine

DRUG

Guanfacine 1mg

DRUG

Guanfacine 2mg

DRUG

Placebo

Sponsors & Collaborators

  • National Institutes of Health (NIH)

    collaborator NIH

  • National Institute on Drug Abuse (NIDA)

    collaborator NIH

  • Massachusetts General Hospital

    lead OTHER

Principal Investigators

  • Jianren Mao, M.D., Ph.D. · Massachusetts General Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-09-30
Primary Completion
2022-12-31
Completion
2023-12-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs
Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01681264 on ClinicalTrials.gov