Reliability of Pupil Response to Acute Pain
NCT02628314 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 20
Last updated 2026-04-29
Summary
The purpose of this research study is to test whether researchers can reliably measure the response pupils have when an acute painful stimulus is experienced. Changes in the size of the pupil of the eye can be an indicator of brain activity in a region of the brain that is important for feeling pain.
Conditions
Sponsors & Collaborators
-
Wake Forest University Health Sciences
lead OTHER
Principal Investigators
-
James C Eisenach, MD · Wake Forest University Health Sciences
Eligibility
- Min Age
- 18 Years
- Max Age
- 70 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2015-08-04
- Primary Completion
- 2025-06-16
- Completion
- 2025-06-16
Countries
- United States
Study Locations
More Related Trials
-
Effect of Ambient Light on the Parameters of the Pupillary Light Reflex
NCT01207817 ·Status: COMPLETED
-
Establishing Normative Data for Pupillometer Assessments in Neuro-Intensive Care
NCT02804438 ·Status: RECRUITING
-
Pupillometry for the Prediction of Neurologic Outcomes in Severe Traumatic Brain Injury
NCT02465242 ·Status: UNKNOWN
-
Non-intrusive Detection of Temporary Neurologic Impairment By Opioids
NCT04223609 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Interrater Reliability of Subjective Pupillary Assessments
NCT02296606 ·Status: COMPLETED
-
Pupillometry Use & Professional's Inspection : Leveling Subjectivity
NCT06733207 ·Status: COMPLETED
-
Near-InfraRed Spectroscopy of Auricular Stimulation
NCT06825364 ·Status: RECRUITING ·Phase: NA
-
Validation of Clinical Outcome Measures Specific to mTBI-Related Oculomotor Disorders
NCT07282691 ·Status: RECRUITING
-
Eye Movements, Visual Perception and Attention
NCT03884985 ·Status: COMPLETED ·Phase: NA
-
Ultrasound Biomicroscopy Study Of Accommodative State In Smartphone Abusers
NCT03389009 ·Status: COMPLETED
-
A Pilot Study for Pupillary Assessment to Predict CAR-T Related Neurotoxicity
NCT06144151 ·Status: RECRUITING
-
The Effects of Acute vs. Chronic of Screen Illumination on: Sleep Efficacy and Architecture, Physiology, Emotion and Behavior: Possible Effect on Human Health
NCT02839395 ·Status: COMPLETED ·Phase: NA
-
Visual Attention and Eye Movements
NCT03298737 ·Status: ENROLLING_BY_INVITATION
-
Ocular-vestibular Biomarker Identification for ADHD
NCT04504890 ·Status: UNKNOWN
-
Oculomotor Assessment of Traumatic Brain Injury (TBI)
NCT03156010 ·Status: COMPLETED ·Phase: NA
-
Oxytocin Effect on Attention Inhibition
NCT03486925 ·Status: COMPLETED ·Phase: NA
-
How Accurately Does the Diopsys Visual Evoked Potential (VEP) Vision Testing System Detect Glaucoma?
NCT02622178 ·Status: COMPLETED ·Phase: NA
-
Investigation of Pupillometry as Guide for Extubation Readiness in Anesthetized Children
NCT04947397 ·Status: COMPLETED ·Phase: NA
-
Normal Eyelid Sensation Distribution
NCT02059824 ·Status: COMPLETED ·Phase: NA
-
Pilot Study of TENS for Ocular Pain
NCT05531643 ·Status: COMPLETED ·Phase: NA
-
Effect of Different Color Lights on the Internal Clock and Alertness in Humans
NCT05423002 ·Status: UNKNOWN ·Phase: NA
-
Oxytocin's Effect on Attention Training
NCT03128242 ·Status: UNKNOWN ·Phase: NA
-
Safety and Normative Data With Neos™
NCT07258212 ·Status: RECRUITING
-
Impact of Acute Cerebral Diseases on the Autonomous Nervous System: Progression and Correlation to Therapy and Outcome
NCT02999659 ·Status: UNKNOWN
-
The Neurological Pupil Index (NPi) on Intensive Care Unit (ICU) Trial
NCT01920347 ·Status: COMPLETED