Clinical Trials Updated in 2025

NCT06648915 | ACTIVE_NOT_RECRUITING

364 participants

Lipoprotein(a) and Progression of Aortic Stenosis

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-29
Start Date:: 2025-02-10
Completion:: 2026-02-28

Conditions

Aortic Valve Stenosis
Lipoprotein(a)

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT06645808 | RECRUITING | EARLY_PHASE1

32 participants

PET-imaging of Two Vartumabs in Patients With Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-29
Start Date:: 2024-12-10
Completion:: 2026-08-31

Conditions

Solid Tumor
Colon Carcinoma
Rectal Carcinoma
Osteosarcoma
Chondrosarcoma
Lung Carcinoma
Head and Neck Squamous Cell Carcinoma
Esophageal Carcinoma
Gastric Carcinoma
Pancreas Carcinoma
Bladder Carcinoma
Glioblastoma
Soft Tissue Sarcoma (STS)
Breast Cancer

Interventions

BIOLOGICAL
RADIATION

No Results Yet

NCT06640894 | RECRUITING | NA

66 participants

Power2Walk: The Impact of Functional Power Training on Participation and Activity in Children With Cerebral Palsy.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-29
Start Date:: 2024-07-19
Completion:: 2027-08-31

Conditions

Cerebral Palsy, Spastic

Interventions

OTHER

No Results Yet

NCT06629649 | RECRUITING | NA

1800 participants

Implementing AI-based Glaucoma Screening Within Federally Qualified Health Centers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-29
Start Date:: 2025-10-22
Completion:: 2029-09-29

Conditions

Glaucoma
Ocular Hypertension

Interventions

OTHER

No Results Yet

NCT06626659 | COMPLETED

40 participants

Lipoprotein (a) and Vascular Regenerative Cell Content

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-29
Start Date:: 2024-10-05
Completion:: 2024-12-03

Conditions

Cardiovascular Diseases
Atherosclerosis Cardiovascular Disease
Ischemic Heart Disease
Dyslipidemia

No Results Yet

NCT06625541 | COMPLETED | PHASE1

57 participants

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AJ302-IM in Healthy Volunteers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-29
Start Date:: 2024-06-24
Completion:: 2025-08-15

Conditions

Healthy Volunteers

Interventions

DRUG

No Results Yet

NCT06614270 | RECRUITING | NA

15 participants

Anti-CD19 IL-10/IL15 CAR-NK Cells in Refractory/Relapsed Autoimmune Diseases

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-29
Start Date:: 2025-01-06
Completion:: 2026-01-06

Conditions

Systemic Sclerosis (SSc)
ANCA Associated Vasculitis (AAV)
Idiopathic Inflammatory Myopathy (IIM)
Sjogren's Syndrome
Antiphospholipid Syndrome
Systemic Lupus Erythematosus

Interventions

DRUG

No Results Yet

NCT06603181 | COMPLETED | NA

60 participants

Effect of Extracorporeal Shock Wave Therapy (ESWT) and Phonophoresis Treatment in Patients With Lateral Epicondylitis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-29
Start Date:: 2024-09-25
Completion:: 2025-01-30

Conditions

Lateral Epicondylitis
Extracorporeal Shock Wave Therapy
Phonophoresis

Interventions

OTHER

No Results Yet

NCT06602037 | RECRUITING | NA

90 participants

ImmunoPET Imaging of Pancreatic Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-29
Start Date:: 2024-11-20
Completion:: 2027-06-30

Conditions

Neoplasms Pancreatic

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT06588205 | RECRUITING

200 participants

Exploring the Clinical Impact of MYC Aberrations and Their Relationship With Microenvironment in Diffuse Large B Cell Lymphoma and High-Grade B Cell Lymphoma

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-29
Start Date:: 2025-05-05
Completion:: 2027-12-31

Conditions

Diffuse Large B Cell Lymphoma
High-grade B-cell Lymphoma
High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements

No Results Yet

NCT06587386 | COMPLETED | PHASE4

55 participants

The Minimum Effective Dose (ED90) of Liposomal Bupivacaine for Preserving Motor Function

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-29
Start Date:: 2025-05-20
Completion:: 2025-11-10

Conditions

Motion Sickness

Interventions

DRUG

No Results Yet

NCT06581627 | COMPLETED | PHASE1

24 participants

A Research Study Looking at a Single Dose of Etavopivat in Healthy Chinese Participants

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-29
Start Date:: 2024-08-26
Completion:: 2024-10-31

Conditions

Healthy Volunteers
Sickle Cell Disease
Thalassemia

Interventions

DRUG

No Results Yet

NCT06562673 | COMPLETED | PHASE1/PHASE2

10 participants

Intra-arterial Cisplatin Plus Rh-endostatin Combined With Systematic Chemotherapy in Osteosarcoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-29
Start Date:: 2024-12-03
Completion:: 2025-04-17

Conditions

Osteosarcoma
Bone Cancer

Interventions

DRUG

No Results Yet

NCT06559371 | RECRUITING

150 participants

68Ga FAPI PET/CT Evaluation of Axillary Lymph Node Status After Neoadjuvant Therapy in Patients With Clinical Axillary Lymph Node Positive Breast Cancer

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-29
Start Date:: 2024-08-30
Completion:: 2026-06-30

Conditions

BREAST CANCER
PET/CT

No Results Yet

NCT06549699 | COMPLETED | NA

206 participants

Medically Used Tailored Traditional Food to Optimize Nutrition in Heart Failure

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-29
Start Date:: 2025-05-12
Completion:: 2025-11-11

Conditions

Heart Failure

Interventions

OTHER

No Results Yet

NCT06542874 | COMPLETED | PHASE2

448 participants

A Research Study Comparing How Well Different Doses of the Medicine NNC0487-0111 Lower Blood Sugar in People With Type 2 Diabetes

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-29
Start Date:: 2024-08-07
Completion:: 2025-10-01

Conditions

Type 2 Diabetes (T2D)

Interventions

DRUG

No Results Yet

NCT06535659 | RECRUITING

122 participants

VitaFlow LIBERTY Europe

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-29
Start Date:: 2025-05-06
Completion:: 2027-06-06

Conditions

Aortic Valve Stenosis

Interventions

DEVICE

No Results Yet

NCT06534723 | RECRUITING | PHASE3

570 participants

Phase 3 Clinical Trial of Wujia Yizhi Granules in the Treatment of Mild-to-moderate Alzheimer's Dementia (Syndrome of Deficiency of Spleen and Kidney)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-29
Start Date:: 2024-08-20
Completion:: 2026-08-31

Conditions

Alzheimer's Dementia

Interventions

DRUG

No Results Yet

NCT06525532 | RECRUITING

35 participants

Clinical-MRI Evaluation in Patients Undergoing Subtalar Arthrorisis With Reabsorbable Endorthesis Implant in PLLA

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-29
Start Date:: 2024-06-12
Completion:: 2026-11-30

Conditions

Lower Limb Deformity

Interventions

OTHER

No Results Yet

NCT06522932 | RECRUITING | PHASE1

32 participants

PET Imaging Study of 64Cu-GRIP B for Patients Receiving CD19-directed CAR-T Therapy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-29
Start Date:: 2024-10-23
Completion:: 2027-01-31

Conditions

Non Hodgkin Lymphoma

Interventions

DRUG
PROCEDURE

No Results Yet

NCT06510998 | RECRUITING | NA

390 participants

Isometric Resistance Exercise for Hypertension

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-29
Start Date:: 2025-01-01
Completion:: 2027-07-28

Conditions

Hypertension

Interventions

BEHAVIORAL

No Results Yet

NCT06494189 | COMPLETED | PHASE1

9 participants

Low-dose Radiotherapy Plus Tislelizumab in Combination With Afatinib for Neoadjuvant Treatment of Surgically Resectable Head and Neck Squamous Carcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-29
Start Date:: 2024-07-31
Completion:: 2025-04-10

Conditions

Head and Neck Cancer

Interventions

BIOLOGICAL
DRUG
RADIATION

No Results Yet

NCT06492434 | COMPLETED | NA

16 participants

Enhancing Community Participation Through Peer-Delivered Decision Support

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-29
Start Date:: 2024-07-01
Completion:: 2025-08-31

Conditions

Severe Mental Disorder

Interventions

BEHAVIORAL

No Results Yet

NCT06414967 | RECRUITING | NA

15 participants

Study to Evaluate Music Therapy on Irritability and Impulsivity in Patients With Huntington's Disease (MUSIC-HD)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-29
Start Date:: 2024-10-15
Completion:: 2026-07-31

Conditions

Huntington Disease

Interventions

OTHER

No Results Yet

NCT06400706 | COMPLETED | NA

92 participants

Effect of Electroencephalography Guided General Anesthesia on Postoperative Delirium in Children

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-29
Start Date:: 2024-05-15
Completion:: 2024-12-15

Conditions

Postoperative Delirium
Postoperative Pain

Interventions

PROCEDURE

No Results Yet

NCT06380660 | RECRUITING | PHASE1/PHASE2

298 participants

Study of ACE-86225106 to Treat Patients With Advanced Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-29
Start Date:: 2024-03-22
Completion:: 2028-12-21

Conditions

Solid Tumor, Adult
BRCA1 Mutation
BRCA2 Mutation
Ovarian Cancer
Breast Cancer
Prostate Cancer

Interventions

DRUG

No Results Yet

NCT06367465 | RECRUITING

50 participants

Feasibility and Acceptability of HCV Treatment in Pregnancy

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-29
Start Date:: 2024-02-01
Completion:: 2026-02-28

Conditions

Hepatitis C
Pregnancy Complications

Interventions

DRUG

No Results Yet

NCT06350890 | COMPLETED | PHASE3

408 participants

Efficacy and Safety of Berberine Ursodeoxycholate (HTD1801) in Patients With Type 2 Diabetes

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-29
Start Date:: 2023-11-05
Completion:: 2024-12-12

Conditions

T2DM (Type 2 Diabetes Mellitus)

Interventions

DRUG

No Results Yet

NCT06343870 | RECRUITING | PHASE3

140 participants

Estradiol and Testosterone Subdermal Implants for Menopause Treatment (ESTIME)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-29
Start Date:: 2025-12-18
Completion:: 2026-08-18

Conditions

Menopause
Testosterone Deficiency
Estrogen Deficiency

Interventions

DRUG

No Results Yet

NCT06335524 | RECRUITING | NA

188 participants

Infant-Maternal Partnership and Cognitive Training Study for Preterm Infants

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-29
Start Date:: 2024-11-01
Completion:: 2026-12-31

Conditions

Child Development
Infant Development
Infant, Premature, Diseases

Interventions

BEHAVIORAL

No Results Yet

NCT06320405 | RECRUITING | PHASE1/PHASE2

38 participants

Axatilimab in Combination With Retifanlimab and Paclitaxel for the Treatment of Patients With Advanced or Metastatic Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-29
Start Date:: 2024-05-21
Completion:: 2027-04-01

Conditions

Advanced Malignant Solid Neoplasm
Metastatic Malignant Solid Neoplasm
Recurrent Malignant Solid Neoplasm
Refractory Malignant Solid Neoplasm

Interventions

BIOLOGICAL
PROCEDURE
DRUG

No Results Yet

NCT06291285 | COMPLETED | PHASE1

44 participants

A Study to Test How Either a Capsule or a Tablet With NDec (Decitabine and Tetrahydrouridine) Works in the Body of Healthy People

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-29
Start Date:: 2024-02-27
Completion:: 2024-06-10

Conditions

Healthy Volunteers

Interventions

DRUG

No Results Yet

NCT06285760 | RECRUITING

64 participants

Effect of Acetazolamide on Diuresis and Natriuresis in Patients With Acute Heart Failure (SANDI STUDY)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-29
Start Date:: 2024-03-01
Completion:: 2026-05-31

Conditions

Heart Failure
Persistent Congestion

Interventions

DRUG

No Results Yet

NCT06271265 | RECRUITING | PHASE1

48 participants

Study to Evaluate the Pharmacokinetics and Safety of EXPAREL for Postoperative Analgesia in Subjects Undergoing Cardiac Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-29
Start Date:: 2024-03-29
Completion:: 2027-01-31

Conditions

Postoperative Pain

Interventions

DRUG

No Results Yet

NCT06251986 | COMPLETED

310 participants

A Cross-sectional Study to Assess the Effectiveness and Safety of Ofatumumab (Kesimpta®) in Patients With Relapsing Multiple Sclerosis in the Spanish Clinical Practice

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-29
Start Date:: 2024-02-26
Completion:: 2024-12-23

Conditions

Relapsing Forms of Multiple Sclerosis

Interventions

OTHER

No Results Yet

NCT06249178 | RECRUITING

1000 participants

EV Based Platform for Monitoring Therapeutics Response During Pregnancy (ARISE)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-29
Start Date:: 2024-07-02
Completion:: 2028-09-01

Conditions

Preeclampsia

No Results Yet

NCT06193057 | RECRUITING | NA

24 participants

Comparison of Customized and Standard Total Ankle Prostheses

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-29
Start Date:: 2023-07-26
Completion:: 2026-04-30

Conditions

Ankle Osteoarthritis

Interventions

PROCEDURE

No Results Yet

NCT06173063 | TERMINATED | NA

19 participants

Safety and Effectiveness of A Novel Enteral Feeding System: Prospective Study.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-29
Start Date:: 2023-11-14
Completion:: 2024-11-06

Conditions

Enteral Feeding

Interventions

DEVICE

Results Available

NCT06147531 | RECRUITING | PHASE2

150 participants

Delayed Cold-Stored Platelets -PLTS-1

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-29
Start Date:: 2024-06-05
Completion:: 2026-06-30

Conditions

Platelets
Bleeding
Cardiopulmonary Bypass
Cardiac Surgery

Interventions

BIOLOGICAL

No Results Yet

NCT06092671 | RECRUITING | NA

444 participants

Effect of FPCA on Incidence of Emergency Delirium in Children After Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-29
Start Date:: 2023-10-24
Completion:: 2026-09-30

Conditions

Postoperative Complications
Child
Family
Emergence Delirium
General Anaesthesia
Perioperative Care

Interventions

OTHER

No Results Yet