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Lipoprotein(a) and Progression of Aortic Stenosis

NCT06648915 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 364

Last updated 2025-12-29

No results posted yet for this study

Summary

This study is a prospective, observational, two arm parallel group, clinical study involving patients with measurements of Lp(a) and mild to moderate aortic stenosis. A total of 1381 patients underwent measurement of Lp(a) and had a diagnosis of mild to moderate, degenerative aortic stenosis between 2001 and 2020 in Asan Medical Center. Investigators selected a propensity-matched cohort of patients with Lp(a) \>70 mg/dL and those with Lp(a) \<30 mg/dL from the registry of patients with mild to moderate aortic stenosis to control risk factors for progression of aortic stenosis, and try to prospectively compare progression of aortic stenosis between the two groups (Lp(a) \>70 mg/dL versus Lp(a) \< 30 mg/dL). Investigators also evaluate interactions between Lp(a) groups and baseline clinical and echocardiographic variables for progression of aortic stenosis.

Conditions

  • Aortic Valve Stenosis
  • Lipoprotein(a)

Interventions

DIAGNOSTIC_TEST

Lipoprotein(a)

Measurement of Lp(a) was performed at the time of entry to the registry. Lp(a) level was measured using immunenephelometric assay

Sponsors & Collaborators

  • Asan Medical Center

    lead OTHER

Principal Investigators

  • Duk-Hyun Kang, MD. PhD. · Asan Medical Center

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-02-10
Primary Completion
2026-02-28
Completion
2026-02-28

Countries

  • South Korea

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06648915 on ClinicalTrials.gov