Clinical Trials Updated in 2025

NCT04981288 | ACTIVE_NOT_RECRUITING

24 participants

Lipids and Energy Study: Optimizing the Analysis of Lipids and Energy Metabolism in Blood Samples

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-09
Start Date:: 2021-07-02
Completion:: 2025-08-01

Conditions

Healthy

No Results Yet

NCT04908254 | COMPLETED | NA

50 participants

A Multi-center Randomized Control Cross-over Study to Evaluate the Safety and Effectiveness of the Dayspring Active Wearable Compression Device vs. an Advanced Pneumatic Compression Device for Treating Breast Cancer Related Lymphedema

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2021-06-01
Completion:: 2021-12-31

Conditions

Lymphedema
Lymphedema of Upper Arm
Lymphedema, Breast Cancer

Interventions

DEVICE

No Results Yet

NCT04866576 | COMPLETED | NA

62 participants

Effect of a Fermented Soy Product on Cognition, Immune Status and Vaccine

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2021-08-12
Completion:: 2022-03-01

Conditions

Cognitive Change
Inflammation
Immune Response

Interventions

DIETARY_SUPPLEMENT

No Results Yet

NCT04863664 | COMPLETED | NA

998 participants

Lead EvaluAtion for Defibrillation and Reliability (LEADR) / Lead Evaluation for Defibrillation and Reliability in Left Bundle Branch Area Pacing (LEADR LBBAP)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2021-06-21
Completion:: 2025-09-03

Conditions

Tachyarrhythmia

Interventions

DEVICE

No Results Yet

NCT04825379 | ACTIVE_NOT_RECRUITING | NA

31 participants

Clinical Evaluation of a Bioactive Material

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2021-06-01
Completion:: 2021-09-01

Conditions

Tooth Disease

Interventions

DEVICE

No Results Yet

NCT04796792 | RECRUITING | NA

140 participants

Ultrasound to Facilitate Stone Passage

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2023-04-01
Completion:: 2028-05-31

Conditions

Urinary Stone
Urinary Calculi

Interventions

DEVICE

No Results Yet

NCT04784416 | ACTIVE_NOT_RECRUITING | PHASE2

196 participants

Transcranial Photobiomodulation for Alzheimer's Disease (TRAP-AD)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2021-04-27
Completion:: 2025-10-30

Conditions

Mild Cognitive Impairment
Alzheimer Disease

Interventions

DEVICE
DRUG

No Results Yet

NCT04745728 | RECRUITING | PHASE3

200 participants

Different Immunosuppressive Treatment in iMN

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2021-04-14
Completion:: 2027-12-31

Conditions

Idiopathic Membranous Nephropathy

Interventions

DRUG

No Results Yet

NCT04743739 | TERMINATED | PHASE3

12 participants

Rituximab Combined With Cyclosporine Versus Rituximab Alone in the Treatment of iMN

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2021-04-14
Completion:: 2022-12-20

Conditions

Idiopathic Membranous Nephropathy

Interventions

DRUG

No Results Yet

NCT04738422 | ENROLLING_BY_INVITATION | PHASE2

150 participants

Determining Airway pH by Compartmental Exhaled Nitric Oxide Levels During Alkaline Buffer Challenge

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2020-09-11
Completion:: 2028-07-15

Conditions

Airway Disease

Interventions

DRUG

No Results Yet

NCT04735367 | COMPLETED

42 participants

Study to Evaluate Overall Survival in Japanese Patients With HR+/HER2- Advanced Breast Cancer Treated With Palbociclib Plus Letrozole

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-09
Start Date:: 2021-02-03
Completion:: 2023-09-29

Conditions

Breast Cancer

Interventions

DRUG

Results Available

NCT04707469 | COMPLETED | PHASE3

1606 participants

Research Study to Compare Three Doses of Semaglutide Tablets Taken Once Daily in People With Type 2 Diabetes

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2021-01-15
Completion:: 2023-03-07

Conditions

Diabetes Mellitus, Type 2

Interventions

DRUG

Results Available

NCT04677946 | NOT_YET_RECRUITING | NA

16 participants

Dietary Oil to Improve Sleep Quality

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2027-12-31
Completion:: 2028-12-31

Conditions

Insomnia Type; Sleep Disorder

Interventions

OTHER

No Results Yet

NCT04669093 | NOT_YET_RECRUITING | NA

60 participants

Individual Differences in Placebo Analgesic Effects

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2026-09-30
Completion:: 2027-12-31

Conditions

Healthy

Interventions

BEHAVIORAL

No Results Yet

NCT04650841 | NOT_YET_RECRUITING | EARLY_PHASE1

60 participants

The Role of the Opioid System in Placebo Effects on Pain and Social Rejection

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2026-09-01
Completion:: 2027-03-01

Conditions

Pain
Rejection
Placebo Effect

Interventions

DRUG

No Results Yet

NCT04609553 | COMPLETED | NA

662 participants

Literacy Promotion for Latinos Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2020-11-16
Completion:: 2024-12-28

Conditions

Language Development
Behavior, Child
Parenting
Literacy

Interventions

BEHAVIORAL

Results Available

NCT04598893 | ACTIVE_NOT_RECRUITING

188 participants

Recent-Onset Type 1 Diabetes Extension Study Evaluating the Long-Term Safety of Teplizumab (PROTECT Extension)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-09
Start Date:: 2020-10-26
Completion:: 2026-11-30

Conditions

Diabetes Mellitus, Type 1

Interventions

BIOLOGICAL
OTHER

No Results Yet

NCT04550936 | COMPLETED

307 participants

A Study to Understand How the Use of Paxlovid Affected the Healthcare Use in People With Pre-existing Conditions.

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-09
Start Date:: 2021-03-10
Completion:: 2023-12-23

Conditions

Invasive Aspergillosis
Mucormycosis

Interventions

DRUG

Results Available

NCT04540380 | ACTIVE_NOT_RECRUITING | PHASE1

20 participants

Renal Allograft Tolerance Through Mixed Chimerism - SMC/MGH

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2021-09-01
Completion:: 2027-01-31

Conditions

Renal Failure

Interventions

DRUG
PROCEDURE

No Results Yet

NCT04429971 | COMPLETED | NA

26 participants

Pre-Exposure Prophylaxis in the Emergency Department

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2020-03-18
Completion:: 2023-07-31

Conditions

HIV/AIDS
PrEP

Interventions

OTHER

Results Available

NCT04421924 | RECRUITING | NA

39 participants

Periinterventional Coagulation Management of Patients Undergoing a TIPS

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2020-05-27
Completion:: 2026-05-31

Conditions

Liver Cirrhosis

Interventions

PROCEDURE

No Results Yet

NCT04390750 | COMPLETED | NA

60 participants

Care Partner Assisted Intervention to Improve Oral Health of Individuals With Mild Dementia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2021-10-22
Completion:: 2024-03-25

Conditions

Mild Dementia

Interventions

BEHAVIORAL

Results Available

NCT04379414 | ACTIVE_NOT_RECRUITING | NA

400 participants

YES Study - Newly Diagnosed/Metastatic Intervention

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2020-09-16
Completion:: 2027-03-01

Conditions

Breast Cancer
Symptom, Behavioral

Interventions

BEHAVIORAL

No Results Yet

NCT04364646 | COMPLETED | NA

120 participants

Personalized Integrated Chronotherapy for Perinatal Depression

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2020-11-02
Completion:: 2024-10-22

Conditions

Depression
Postpartum Depression
Prenatal Disorder
Circadian Dysregulation
Pregnancy Related
Sleep Disturbance

Interventions

BEHAVIORAL

Results Available

NCT04345718 | COMPLETED | PHASE2/PHASE3

344 participants

EXHIT ENTRE Comparative Effectiveness Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2021-08-09
Completion:: 2025-08-27

Conditions

Substance Use Disorder
Opioid Use Disorder, Moderate
Opioid Use Disorder, Severe

Interventions

DRUG

No Results Yet

NCT04286191 | COMPLETED | NA

21 participants

Physiological Changes Induced Through MEP Conditioning in People With SCI

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2021-02-22
Completion:: 2025-11-30

Conditions

Spinal Cord Injuries
Neurological Injury
Paralysis
Spasticity, Muscle

Interventions

COMBINATION_PRODUCT

No Results Yet

NCT04218370 | COMPLETED | NA

220 participants

Liberation From Acute Dialysis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2020-01-23
Completion:: 2025-06-08

Conditions

Acute Kidney Injury
Kidney; Disease, Acute
Dialysis Related Complication

Interventions

PROCEDURE

No Results Yet

NCT04190225 | COMPLETED | NA

160 participants

Physical Activity Intervention for Adolescent Girls

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2020-08-06
Completion:: 2023-11-21

Conditions

Physical Activity

Interventions

BEHAVIORAL

Results Available

NCT04175639 | COMPLETED | NA

180 participants

mHealth Behavioral Cancer Pain Intervention for Medically Underserved Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2021-10-20
Completion:: 2024-12-20

Conditions

Breast Cancer

Interventions

BEHAVIORAL

Results Available

NCT04167033 | RECRUITING | NA

120 participants

Ventricular Repolarization in Patients With Premature Ovarian Insufficiency (QTIOP)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2021-04-14
Completion:: 2027-04-13

Conditions

Premature Ovarian Insufficiency

Interventions

DRUG
DIAGNOSTIC_TEST

No Results Yet

NCT04063163 | COMPLETED | PHASE3

585 participants

A Phase III Study to Investigate Efficacy and Safety of HLX10 + Chemotherapy in Patients With ES-SCLC

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2019-09-12
Completion:: 2024-05-07

Conditions

Extensive Stage Small Cell Lung Cancer

Interventions

DRUG

Results Available

NCT04044690 | TERMINATED | PHASE3

134 participants

A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of IgPro20 in Adults With Dermatomyositis (DM)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2019-10-21
Completion:: 2024-12-02

Conditions

Dermatomyositis

Interventions

DRUG

Results Available

NCT04008615 | COMPLETED

65 participants

Comparison of the Cardiopulmonary and Gaz-exchange Response Between the Six-minute Stepper Test and the Incremental Cardiopulmonary Exercise Testing in Patients With Chronicle Obstructive Pulmonary Disease

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-09
Start Date:: 2019-08-01
Completion:: 2023-06-30

Conditions

Chronic Obstructive Pulmonary Disease
Pulmonary Rehabilitation
6-minute Stepper Test

Interventions

OTHER

No Results Yet

NCT03935295 | RECRUITING | PHASE4

90 participants

Dysport ® as an Adjunctive Treatment to Bracing in the Management of Adolescent Idiopathic Scoliosis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2020-09-03
Completion:: 2026-12-31

Conditions

Adolescent Idiopathic Scoliosis

Interventions

DRUG
DEVICE

No Results Yet

NCT03829475 | COMPLETED | PHASE2

61 participants

ICON-2: FMT and Bezlotoxumab Compared to FMT and Placebo for Patients With IBD and CDI

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2020-01-01
Completion:: 2023-08-03

Conditions

Inflammatory Bowel Diseases
Clostridium Difficile Infection

Interventions

DRUG

Results Available

NCT03828773 | RECRUITING | NA

410 participants

PTX3-targeted Antifungal Prophylaxis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2019-02-11
Completion:: 2027-11-30

Conditions

Candidiasis
Fungal Infection
Acute Myeloid Leukemia
Genetic Predisposition
Aspergillosis

Interventions

DRUG

No Results Yet

NCT03682848 | COMPLETED | PHASE3

32 participants

Safety and Efficacy of Dolutegravir/Lamivudine (DTG/3TC) in Therapy-naive Human Immunodeficiency Virus-1 (HIV-1) Infected Adolescents

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2019-05-06
Completion:: 2021-12-01

Conditions

HIV Infections

Interventions

DRUG

Results Available

NCT03608033 | TERMINATED | PHASE3

360 participants

Study of the Safety and Efficacy of OMS721 in Patients With Immunoglobulin A (IgA) Nephropathy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2018-04-05
Completion:: 2024-01-12

Conditions

IgA Nephropathy

Interventions

BIOLOGICAL
OTHER

Results Available

NCT03550911 | COMPLETED

14 participants

Biological Collection From Samples From The Gut Microbiota In Patients Having A Bone Or Joint Infection Treated By A Suppressive Subcutaneous Antibiotherapy With Betalactamine (CARBAMICROBIOTA)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-09
Start Date:: 2018-10-11
Completion:: 2024-04-08

Conditions

Bone Infection
Joint Infection

Interventions

OTHER

No Results Yet

NCT03483584 | COMPLETED

215 participants

Incidence of HANA Conditions in HIV-infected Individuals

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-09
Start Date:: 2018-04-06
Completion:: 2024-03-31

Conditions

HIV
Metabolic Syndrome
Osteopenia
Osteoporosis
Vitamin D Deficiency
Renal Impairment
Liver Fibroses

Results Available