Liberation From Acute Dialysis
NCT04218370 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 220
Last updated 2025-12-09
Summary
The goal of the LIBERATE-D clinical trial is to improve outcomes for patients recovering from dialysis-requiring acute kidney injury (AKI-D). The impact of a conservative dialysis strategy compared to standard clinical practice of thrice-weekly dialysis will be examined to help generate knowledge for how to guide delivery of dialysis to facilitate renal recovery.
Conditions
- Acute Kidney Injury
- Kidney; Disease, Acute
- Dialysis Related Complication
Interventions
- PROCEDURE
-
Dialysis
Dialysis treatment, either in the form of hemodialysis or continuous renal replacement therapy (if patient develops hemodynamic instability)
Sponsors & Collaborators
-
Vanderbilt University Medical Center
collaborator OTHER -
National Institutes of Health (NIH)
collaborator NIH -
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
collaborator NIH -
University of California, San Francisco
lead OTHER
Principal Investigators
-
Kathleen Liu, MD, PhD, MAS · University of California, San Francisco
-
Chi-yuan Hsu, MD, MSc · University of California, San Francisco
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2020-01-23
- Primary Completion
- 2025-06-08
- Completion
- 2025-06-08
Countries
- United States
Study Locations
More Related Trials
-
Efficacy of Convection-based HDF Compare With Diffusion-based HD in Sepsis-associated AKI
NCT06227104 ·Status: RECRUITING ·Phase: NA
-
Assisted Peritoneal Dialysis: A Feasibility Study
NCT04319185 ·Status: UNKNOWN ·Phase: NA
-
Regional Anticoagulation of Dialysis Circuits With a Calcium-free Citrate-containing Dialysate
NCT03842657 ·Status: COMPLETED ·Phase: PHASE2
-
Dialysis Weaning in Intensive Care Units (Dialysis STOP)
NCT03763188 ·Status: COMPLETED
-
Skin Autofluorescence as a Risk Marker in People Receiving Dialysis.
NCT02878317 ·Status: COMPLETED
-
Safety and Efficacy Assessments of NeoKidney® in ESRD Patients Treated With Short Daily Hemodialysis
NCT06024135 ·Status: UNKNOWN ·Phase: NA
-
Substitution of Acetate by Citrate in the Bicarbonate Based Hemodialysis
NCT02745340 ·Status: UNKNOWN ·Phase: NA
-
Evaluation of the Optimal Transition Program
NCT04263233 ·Status: UNKNOWN
-
Patient Activation in Dialysis
NCT04066140 ·Status: COMPLETED
-
Effects of Convective Therapies in Dialysis Patients
NCT01583309 ·Status: COMPLETED ·Phase: PHASE3
-
Intermittent ADVOS vs. Hemodialysis in Non-intensive Care Patients With Liver Dysfunction
NCT06129617 ·Status: RECRUITING ·Phase: NA
-
RandomizEd ClinicAL triaL on the Efficacy and saFety of Incremental Hemodialysis (REAL-LIFE)
NCT04360694 ·Status: RECRUITING ·Phase: NA
-
Citrate- Versus Acetate-Based Dialysate in Bicarbonate Haemodialysis: Consequences on Haemodynamics, Coagulation, Acid-Base Status and Electrolytes
NCT00718289 ·Status: COMPLETED ·Phase: PHASE4
-
Preventing Early Dialysis Starts
NCT02183987 ·Status: COMPLETED ·Phase: NA
-
Randomised Evaluation of Sodium Dialysate Levels on Vascular Events
NCT02823821 ·Status: RECRUITING ·Phase: PHASE4
-
Adjuvant Peritoneal Dialysis on a Background of Thrice-Weekly Hemodialysis
NCT02044614 ·Status: TERMINATED ·Phase: NA
-
Effect of Dialysis Dose and Membrane Flux in Maintenance Hemodialysis
NCT00004285 ·Status: COMPLETED ·Phase: NA
-
Tolerance to Hemodialysis in Insulin-Requiring Diabetic Patients: BD vs AFB With Blood Volume Biofeedback
NCT01098149 ·Status: COMPLETED ·Phase: NA
-
Comparative Outcome Measures of Patients Receiving Acute Renal ThErapy Study
NCT04912024 ·Status: COMPLETED
-
Medico-economic Evaluation of the Creation of Arteriovenous Access for Hemodialysis Between Surgical Technique and Endovascular Technique in Patients with End-stage Renal Disease
NCT06679907 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
Safety and Performance Evaluation of multiPlus Dialysate During CRRT
NCT05315817 ·Status: TERMINATED ·Phase: NA
-
Efficacy of Twice Weekly Hemodialysis in Patients With Residual Kidney Function
NCT03874117 ·Status: COMPLETED ·Phase: NA
-
Citrate Versus Heparin for the Lock of Non-tunneled Hemodialysis Catheters in Patients Hospitalised in ICU
NCT01962116 ·Status: COMPLETED ·Phase: PHASE3
-
Novel Treatments in Improving Renal Outcomes in Light Chain Cast Nephropathy
NCT06483139 ·Status: RECRUITING
-
Genes, Fibrinolysis and Endothelial Dysfunction- Dialysis Aim 3
NCT00878969 ·Status: TERMINATED ·Phase: PHASE3