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Individual Differences in Placebo Analgesic Effects

NCT04669093 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2025-12-09

No results posted yet for this study

Summary

This study examines the effects of placebo suggestions tailored to match or mismatch individual participants' motivational styles-an issue of person-situation 'fit' with important effects in public health settings, but which has been ignored in past research.

Conditions

  • Healthy

Interventions

BEHAVIORAL

Placebo cream- "promotion" suggestion

Over-the-counter hand cream will be applied to participants' skin, but they will be told that they are given a highly efficient topical analgesic cream. The suggestion will be based on a "promotion" approach (promoting good feelings).

BEHAVIORAL

Placebo cream- "prevention" suggestion

Over-the-counter hand cream will be applied to participants' skin, but they will be told that they are given a highly efficient topical analgesic cream. The suggestion will be based on a "prevention" approach (preventing pain).

BEHAVIORAL

Control cream

In a control condition, with the same cream as in the placebo interventions, participants will be instructed that the cream is a control cream with no effects.

Sponsors & Collaborators

  • Trustees of Dartmouth College

    lead OTHER

Principal Investigators

  • Tor D Wager, PhD · Dartmouth College

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-09-30
Primary Completion
2027-12-31
Completion
2027-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04669093 on ClinicalTrials.gov